Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection

Sohei Satoi; Yoshiaki Murakami; Fuyuhiko Motoi; Kenichiro Uemura; Manabu Kawai; Masanao Kurata; Masayuki Sho; Ippei Matsumoto; Hiroaki Yanagimoto; Tomohisa Yamamoto; Masamichi Mizuma; Michiaki Unno; Yasushi Hashimoto; Seiko Hirono; Hiroki Yamaue; Goro Honda; Minako Nagai; Yoshiyuki Nakajima; Makoto Shinzeki; Takumi Fukumoto; A. Hon Kwon

doi:10.1007/s11605-014-2637-7

Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection

Sohei Satoi, Yoshiaki Murakami, Fuyuhiko Motoi, Kenichiro Uemura, Manabu Kawai, Masanao Kurata, Masayuki Sho, Ippei Matsumoto, Hiroaki Yanagimoto, Tomohisa Yamamoto, Masamichi Mizuma, Michiaki Unno, Yasushi Hashimoto, Seiko Hirono, Hiroki Yamaue, Goro Honda, Minako Nagai, Yoshiyuki Nakajima, Makoto Shinzeki, Takumi FukumotoA. Hon Kwon

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Results: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY− patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37 %; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY− patients (48 vs. 21 %; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.

Objective: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection.

Methods: In a 2001–2011 database from seven high-volume surgical institutions in Japan, 69 patients (7 %) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY− group). Clinicopathological data and survival were compared between groups.

Original language	English
Pages (from-to)	6-14
Number of pages	9
Journal	Journal of Gastrointestinal Surgery
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s11605-014-2637-7
Publication status	Published - 2014 Jan

Keywords

Adjuvant chemotherapy
Pancreatic ductal adenocarcinoma
Peritoneal carcinomatosis
Peritoneal washing cytology
Survival analysis

ASJC Scopus subject areas

Surgery
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11605-014-2637-7

Cite this

Satoi, S., Murakami, Y., Motoi, F., Uemura, K., Kawai, M., Kurata, M., Sho, M., Matsumoto, I., Yanagimoto, H., Yamamoto, T., Mizuma, M., Unno, M., Hashimoto, Y., Hirono, S., Yamaue, H., Honda, G., Nagai, M., Nakajima, Y., Shinzeki, M., ... Kwon, A. H. (2014). Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection. Journal of Gastrointestinal Surgery, 19(1), 6-14. https://doi.org/10.1007/s11605-014-2637-7

Satoi, S, Murakami, Y, Motoi, F, Uemura, K, Kawai, M, Kurata, M, Sho, M, Matsumoto, I, Yanagimoto, H, Yamamoto, T, Mizuma, M , Unno, M, Hashimoto, Y, Hirono, S, Yamaue, H, Honda, G, Nagai, M, Nakajima, Y, Shinzeki, M, Fukumoto, T & Kwon, AH 2014, 'Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection', Journal of Gastrointestinal Surgery, vol. 19, no. 1, pp. 6-14. https://doi.org/10.1007/s11605-014-2637-7

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title = "Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection",

abstract = "Results: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY− patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37 %; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY− patients (48 vs. 21 %; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.Objective: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection.Methods: In a 2001–2011 database from seven high-volume surgical institutions in Japan, 69 patients (7 %) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY− group). Clinicopathological data and survival were compared between groups.",

keywords = "Adjuvant chemotherapy, Pancreatic ductal adenocarcinoma, Peritoneal carcinomatosis, Peritoneal washing cytology, Survival analysis",

author = "Sohei Satoi and Yoshiaki Murakami and Fuyuhiko Motoi and Kenichiro Uemura and Manabu Kawai and Masanao Kurata and Masayuki Sho and Ippei Matsumoto and Hiroaki Yanagimoto and Tomohisa Yamamoto and Masamichi Mizuma and Michiaki Unno and Yasushi Hashimoto and Seiko Hirono and Hiroki Yamaue and Goro Honda and Minako Nagai and Yoshiyuki Nakajima and Makoto Shinzeki and Takumi Fukumoto and Kwon, {A. Hon}",

note = "Publisher Copyright: {\textcopyright} 2014, The Society for Surgery of the Alimentary Tract.",

year = "2014",

month = jan,

doi = "10.1007/s11605-014-2637-7",

language = "English",

volume = "19",

pages = "6--14",

journal = "Journal of Gastrointestinal Surgery",

issn = "1091-255X",

publisher = "Springer New York",

number = "1",

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TY - JOUR

T1 - Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection

AU - Satoi, Sohei

AU - Murakami, Yoshiaki

AU - Motoi, Fuyuhiko

AU - Uemura, Kenichiro

AU - Kawai, Manabu

AU - Kurata, Masanao

AU - Sho, Masayuki

AU - Matsumoto, Ippei

AU - Yanagimoto, Hiroaki

AU - Yamamoto, Tomohisa

AU - Mizuma, Masamichi

AU - Unno, Michiaki

AU - Hashimoto, Yasushi

AU - Hirono, Seiko

AU - Yamaue, Hiroki

AU - Honda, Goro

AU - Nagai, Minako

AU - Nakajima, Yoshiyuki

AU - Shinzeki, Makoto

AU - Fukumoto, Takumi

AU - Kwon, A. Hon

PY - 2014/1

Y1 - 2014/1

N2 - Results: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY− patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37 %; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY− patients (48 vs. 21 %; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.Objective: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection.Methods: In a 2001–2011 database from seven high-volume surgical institutions in Japan, 69 patients (7 %) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY− group). Clinicopathological data and survival were compared between groups.

AB - Results: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY− patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37 %; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY− patients (48 vs. 21 %; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.Objective: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection.Methods: In a 2001–2011 database from seven high-volume surgical institutions in Japan, 69 patients (7 %) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY− group). Clinicopathological data and survival were compared between groups.

KW - Adjuvant chemotherapy

KW - Pancreatic ductal adenocarcinoma

KW - Peritoneal carcinomatosis

KW - Peritoneal washing cytology

KW - Survival analysis

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U2 - 10.1007/s11605-014-2637-7

DO - 10.1007/s11605-014-2637-7

M3 - Article

C2 - 25316482

AN - SCOPUS:84920613018

SN - 1091-255X

VL - 19

SP - 6

EP - 14

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

IS - 1

ER -

Reappraisal of Peritoneal Washing Cytology in 984 Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Margin-Negative Resection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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