TY - JOUR
T1 - Reassortment between amantadine-resistant and -sensitive H1N1 influenza A viruses generated an amantadine-sensitive virus during the 2007-2008 season
AU - Furuse, Yuki
AU - Suzuki, Akira
AU - Shimizu, Midori
AU - Kishi, Makiko
AU - Sawayama, Rumi
AU - Saito, Mariko
AU - Fuji, Naoko
AU - Nukiwa, Nao
AU - Oshitani, Hitoshi
N1 - Funding Information:
Received 5 June 2009; accepted 17 July 2009; electronically published 29 October 2009. Potential conflicts of interest: none reported. Financial support: KAKENHI (grant 21406014); Japan Society for the Promotion of Science. Y.F. is the recipient of a scholarship from the Honjo International Scholarship Foundation. Reprints or correspondence: Hitoshi Oshitani, Department of Virology, Tohoku University Graduate School of Medicine, 2–1 Seiryou-machi Aoba-ku, Sendai, Japan 980-8575 (oshitanih@ mail.tains.tohoku.ac.jp)
PY - 2009/11
Y1 - 2009/11
N2 - The frequency of the amantadine-resistant H1N1 influenza A virus has been increasing since the 2005-2006 season. It is unclear whether reassortment was involved in this trend. Here, we show that cocirculation of amantadine-resistant and -sensitive strains led to the genesis of amantadine-sensitive reassortant virus during the 2007-2008 season. Thereafter, the reassortant virus predominated. This contrasts with the trend for the H3N2 virus, in which the amantadine-resistant reassortant virus became predominant. The results suggest that it is necessary to monitor genome dynamics to understand the evolution and mechanism of the emergence and spread of antiviral resistance among influenza A viruses.
AB - The frequency of the amantadine-resistant H1N1 influenza A virus has been increasing since the 2005-2006 season. It is unclear whether reassortment was involved in this trend. Here, we show that cocirculation of amantadine-resistant and -sensitive strains led to the genesis of amantadine-sensitive reassortant virus during the 2007-2008 season. Thereafter, the reassortant virus predominated. This contrasts with the trend for the H3N2 virus, in which the amantadine-resistant reassortant virus became predominant. The results suggest that it is necessary to monitor genome dynamics to understand the evolution and mechanism of the emergence and spread of antiviral resistance among influenza A viruses.
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U2 - 10.1086/647989
DO - 10.1086/647989
M3 - Article
C2 - 19874176
AN - SCOPUS:72849144584
SN - 0022-1899
VL - 200
SP - 1766
EP - 1773
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -
