TY - JOUR
T1 - Reassortment between swine influenza A viruses increased their adaptation to humans in pandemic H1N1/09
AU - Furuse, Yuki
AU - Suzuki, Akira
AU - Oshitani, Hitoshi
N1 - Funding Information:
Financial support for this study was provided by Health Labor Sciences research grant 20-005-OH from the Ministry of Health, Labor, and Welfare, Japan. YF is a recipient of a scholarship by Honjo International Scholarship Foundation.
PY - 2010/5
Y1 - 2010/5
N2 - In April 2009, pandemic H1N1/09 influenza, which originated from swine influenza, appeared in North America, and it has since spread globally among humans. It is important to know how swine influenza A virus broke the host barrier to cause a pandemic. We analyzed 673 strains of human, avian, and swine influenza viruses and assessed the internal genes PB2, PB1, PA, NP, M, and NS. Here we found accumulation of mutations in segments that were retained as well as introduced due to genetic reassortment of viruses. The retained segments may have to mutate to accommodate new segments. The mutations caused by interaction among segments retained and introduced due to reassortment between swine influenza viruses may have increased the adaptation of the virus to humans, leading to pandemic H1N1/09. We indicate the sites that probably contributed to the acquisition of efficient human-to-human transmission.
AB - In April 2009, pandemic H1N1/09 influenza, which originated from swine influenza, appeared in North America, and it has since spread globally among humans. It is important to know how swine influenza A virus broke the host barrier to cause a pandemic. We analyzed 673 strains of human, avian, and swine influenza viruses and assessed the internal genes PB2, PB1, PA, NP, M, and NS. Here we found accumulation of mutations in segments that were retained as well as introduced due to genetic reassortment of viruses. The retained segments may have to mutate to accommodate new segments. The mutations caused by interaction among segments retained and introduced due to reassortment between swine influenza viruses may have increased the adaptation of the virus to humans, leading to pandemic H1N1/09. We indicate the sites that probably contributed to the acquisition of efficient human-to-human transmission.
KW - Evolution
KW - Influenza virus
KW - Mutation
KW - Pandemic
KW - Reassortment
UR - http://www.scopus.com/inward/record.url?scp=77951978031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951978031&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2010.01.010
DO - 10.1016/j.meegid.2010.01.010
M3 - Article
C2 - 20117250
AN - SCOPUS:77951978031
SN - 1567-1348
VL - 10
SP - 569
EP - 574
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
IS - 4
ER -
