Recent advances in growth factor receptor research

M. Kanzaki, I. Kojima

Research output: Contribution to journalReview articlepeer-review


Growth factors regulate cell growth, differentiation, migration, and apoptosis by stimulating the intrinsic protein kinase activities of their specific cell surface receptors. Most growth factors such as PDGF, EGF, FGF and IGF-I, bind to receptors with tyrosine kinase activity but members of the TGF-beta supergene family bine to those containing serine/threonine kinase activity. Recently, there has been substantial progress in the research field of growth factor receptors and their signaling mechanisms. This review briefly summerizes the tyrosine kinase receptors and also describes recent works in receptors for the TGF-beta supergene family and their signaling mechanisms.

Original languageEnglish
Pages (from-to)1791-1797
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number7
Publication statusPublished - 1998 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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