Recent advances in understanding of chronic kidney disease

Masaomi Nangaku, Junna Yamaguchi, Tetsuhiro Tanaka

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Chronic kidney disease (CKD) is defined as any condition that causes reduced kidney function over a period of time. Fibrosis, tubular atrophy and interstitial inflammation are the hallmark of pathological features in CKD. Regardless of initial insult, CKD has some common pathways leading CKD to end-stage kidney disease, including hypoxia in the tubulointerstitium and proteinuria. Recent advances in genome editing technologies and stem cell research give great insights to understand the pathogenesis of CKD, including identifications of the origins of renal myofibroblasts and tubular epithelial cells upon injury. Environmental factors such as hypoxia, oxidative stress, and epigenetic factors in relation to CKD are also discussed.

Original languageEnglish
Article number1212
Pages (from-to)1-9
Number of pages9
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'Recent advances in understanding of chronic kidney disease'. Together they form a unique fingerprint.

Cite this