Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

Mei He; Hiroshi Kubo; Konosuke Morimoto; Naoya Fujino; Takaya Suzuki; Toru Takahasi; Mitsuhiro Yamada; Mutsuo Yamaya; Tomoyuki Maekawa; Yasuhiko Yamamoto; Hiroshi Yamamoto

doi:10.1038/embor.2011.28

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

Mei He, Hiroshi Kubo, Konosuke Morimoto, Naoya Fujino, Takaya Suzuki, Toru Takahasi, Mitsuhiro Yamada, Mutsuo Yamaya, Tomoyuki Maekawa, Yasuhiko Yamamoto, Hiroshi Yamamoto

Research output: Contribution to journal › Article › peer-review

167 Citations (Scopus)

Abstract

Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an-eat-me-signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage-mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.

Original language	English
Pages (from-to)	358-364
Number of pages	7
Journal	EMBO Reports
Volume	12
Issue number	4
DOIs	https://doi.org/10.1038/embor.2011.28
Publication status	Published - 2011 Apr 1

Keywords

RAGE
apoptosis
macrophage
phagocytosis
phosphatidylserine

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.1038/embor.2011.28

Cite this

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abstract = "Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an-eat-me-signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage-mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.",

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AU - He, Mei

AU - Kubo, Hiroshi

AU - Morimoto, Konosuke

AU - Fujino, Naoya

AU - Suzuki, Takaya

AU - Takahasi, Toru

AU - Yamada, Mitsuhiro

AU - Yamaya, Mutsuo

AU - Maekawa, Tomoyuki

AU - Yamamoto, Yasuhiko

AU - Yamamoto, Hiroshi

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an-eat-me-signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage-mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.

AB - Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an-eat-me-signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage-mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.

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KW - macrophage

KW - phagocytosis

KW - phosphatidylserine

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Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

Abstract

Keywords

ASJC Scopus subject areas

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