Recurrent hypogeusia in a patient with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

Norihiko Kawaguchi, Naoto Sugeno, Kaoru Endo, Emiko Miura, Tatsuro Misu, Ichiro Nakashima, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Hypogeusia, a condition with diminished sense of taste, is caused by several conditions, including zinc deficiency and as a side-effect of drugs, but is not common in neurological disorders. A 55-year-old Japanese man with a 30-year history of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) presented with hypogeusia during hospitalization for a recurrence of CIDP. The hypogeusia improved after treatment with high-dose intravenous methylprednisolone (HIMP). Two years later, hypogeusia developed again. A complete taste deficit was revealed by a filter paper test. Brain MRI showed enhancement of the bilateral facial nerve ganglia. Hypogeusia was partially ameliorated after extensive immunosuppressive therapy with repeated HIMP and plasma exchange. Improvement was more prominent in the area innervated by the chorda tympani nerve than that innervated by the glossopharyngeal nerve. To our knowledge, this is the first report of recurrent hypogeusia, which might be caused by cranial nerve injury associated with CIDP.

Original languageEnglish
Pages (from-to)604-605
Number of pages2
JournalJournal of Clinical Neuroscience
Issue number4
Publication statusPublished - 2012 Apr


  • CIDP
  • Cranial neuropathy
  • Facial nerve
  • Hypogeusia
  • Plasma exchange
  • Steroid pulse therapy


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