Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

Yota Sato; Taku Fujimura; Yumi Kambayashi; Akira Tsukada; Takanori Hidaka; Kayo Tanita; Takahiro Haga; Akira Hashimoto; Setsuya Aiba

doi:10.1159/000456001

Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

Yota Sato, Taku Fujimura, Yumi Kambayashi, Akira Tsukada, Takanori Hidaka, Kayo Tanita, Takahiro Haga, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.

Original language	English
Pages (from-to)	106-111
Number of pages	6
Journal	Case Reports in Oncology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1159/000456001
Publication status	Published - 2017 Jan 6

Keywords

Carcinogenesis
Cutaneous squamous cell carcinoma
IL-17/IL-17R
Signaling

ASJC Scopus subject areas

Oncology

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10.1159/000456001

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abstract = "Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.",

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AU - Sato, Yota

AU - Fujimura, Taku

AU - Kambayashi, Yumi

AU - Tsukada, Akira

AU - Hidaka, Takanori

AU - Tanita, Kayo

AU - Haga, Takahiro

AU - Hashimoto, Akira

AU - Aiba, Setsuya

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Y1 - 2017/1/6

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AB - Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.

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Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

Abstract

Keywords

ASJC Scopus subject areas

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