Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility

Katsuhiko Ono; Takaaki Akaike; Tomohiro Sawa; Yoshito Kumagai; David A. Wink; Dean J. Tantillo; Adrian J. Hobbs; Peter Nagy; Ming Xian; Joseph Lin; Jon M. Fukuto

doi:10.1016/j.freeradbiomed.2014.09.007

Redox chemistry and chemical biology of H₂S, hydropersulfides, and derived species: Implications of their possible biological activity and utility

Katsuhiko Ono, Takaaki Akaike, Tomohiro Sawa, Yoshito Kumagai, David A. Wink, Dean J. Tantillo, Adrian J. Hobbs, Peter Nagy, Ming Xian, Joseph Lin, Jon M. Fukuto

MED - Public Health

Research output: Contribution to journal › Review article › peer-review

301 Citations (Scopus)

Abstract

Hydrogen sulfide (H₂S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H₂S that may play critical physiological roles. Herein, the basic chemical biology of H₂S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H₂S and which may be important biological effectors themselves.

Original language	English
Pages (from-to)	82-94
Number of pages	13
Journal	Free Radical Biology and Medicine
Volume	77
DOIs	https://doi.org/10.1016/j.freeradbiomed.2014.09.007
Publication status	Published - 2014 Dec

Keywords

Hydrogen sulfide
Persulfides
Polysulfides
Thiol redox
Thiols

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10.1016/j.freeradbiomed.2014.09.007

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Ono, K., Akaike, T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., & Fukuto, J. M. (2014). Redox chemistry and chemical biology of H₂S, hydropersulfides, and derived species: Implications of their possible biological activity and utility. Free Radical Biology and Medicine, 77, 82-94. https://doi.org/10.1016/j.freeradbiomed.2014.09.007

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abstract = "Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.",

keywords = "Hydrogen sulfide, Persulfides, Polysulfides, Thiol redox, Thiols",

author = "Katsuhiko Ono and Takaaki Akaike and Tomohiro Sawa and Yoshito Kumagai and Wink, {David A.} and Tantillo, {Dean J.} and Hobbs, {Adrian J.} and Peter Nagy and Ming Xian and Joseph Lin and Fukuto, {Jon M.}",

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Ono, K, Akaike, T, Sawa, T, Kumagai, Y, Wink, DA, Tantillo, DJ, Hobbs, AJ, Nagy, P, Xian, M, Lin, J & Fukuto, JM 2014, 'Redox chemistry and chemical biology of H₂S, hydropersulfides, and derived species: Implications of their possible biological activity and utility', Free Radical Biology and Medicine, vol. 77, pp. 82-94. https://doi.org/10.1016/j.freeradbiomed.2014.09.007

TY - JOUR

T1 - Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species

T2 - Implications of their possible biological activity and utility

AU - Ono, Katsuhiko

AU - Akaike, Takaaki

AU - Sawa, Tomohiro

AU - Kumagai, Yoshito

AU - Wink, David A.

AU - Tantillo, Dean J.

AU - Hobbs, Adrian J.

AU - Nagy, Peter

AU - Xian, Ming

AU - Lin, Joseph

AU - Fukuto, Jon M.

PY - 2014/12

Y1 - 2014/12

N2 - Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.

AB - Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.

KW - Hydrogen sulfide

KW - Persulfides

KW - Polysulfides

KW - Thiol redox

KW - Thiols

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DO - 10.1016/j.freeradbiomed.2014.09.007

M3 - Review article

C2 - 25229186

AN - SCOPUS:84908432800

SN - 0891-5849

VL - 77

SP - 82

EP - 94

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Redox chemistry and chemical biology of H₂S, hydropersulfides, and derived species: Implications of their possible biological activity and utility

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Keywords

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