TY - JOUR
T1 - Redox cycling-based electrochemical CMOS imaging sensor for real time and selective imaging of redox analytes
AU - Abe, Hiroya
AU - Yabu, Hiroshi
AU - Kunikata, Ryota
AU - Suda, Atsushi
AU - Matsudaira, Masahki
AU - Matsue, Tomokazu
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research (A) (no. 16H02280 and no. 17H01223 ), Young Scientists (no. 19K15598 ), Special Coordination Funds for Promoting Science and Technology, the Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program from the Japan Science and Technology Agency, and Grant-in-Aid for JSPS Fellows (No. 16J02105 ) from the Japan Society for the Promotion of Science (JSPS). This work was also supported by a Grant-in-Aid of Tohoku University Institute for International Advanced Research and Education.
Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research (A) (no. 16H02280 and no. 17H01223), Young Scientists (no. 19K15598), Special Coordination Funds for Promoting Science and Technology, the Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program from the Japan Science and Technology Agency, and Grant-in-Aid for JSPS Fellows (No. 16J02105) from the Japan Society for the Promotion of Science (JSPS). This work was also supported by a Grant-in-Aid of Tohoku University Institute for International Advanced Research and Education.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - In this study, we have developed a novel electrochemical device (IDEA-Bio-LSI) incorporating interdigitated electrodes array (IDEA) and a LSI-based amperometric device (Bio-LSI) for high speed (4–200 ms) and selective imaging of an analyte diffusion and cellar activities such as dopamine release. The amplification factor (ηamp) and capture efficiency (CE) of IDEA of the device were 2.17 and 0.767, respectively. Compared with previously reported IDE based imaging sensor, the acquisition speed of the present device to acquire one image was improved up to 50–250 times. In addition, the dopamine release from PC12 spheroids in the presence of ascorbic acid was successfully obtained by using the IDEA-Bio-LSI. Therefore, IDEA-Bio-LSI can apply to rapid analyte diffusion biological events such as release of dopamine release.
AB - In this study, we have developed a novel electrochemical device (IDEA-Bio-LSI) incorporating interdigitated electrodes array (IDEA) and a LSI-based amperometric device (Bio-LSI) for high speed (4–200 ms) and selective imaging of an analyte diffusion and cellar activities such as dopamine release. The amplification factor (ηamp) and capture efficiency (CE) of IDEA of the device were 2.17 and 0.767, respectively. Compared with previously reported IDE based imaging sensor, the acquisition speed of the present device to acquire one image was improved up to 50–250 times. In addition, the dopamine release from PC12 spheroids in the presence of ascorbic acid was successfully obtained by using the IDEA-Bio-LSI. Therefore, IDEA-Bio-LSI can apply to rapid analyte diffusion biological events such as release of dopamine release.
KW - Cell analysis
KW - Dopamine
KW - Electrochemical bioimaging
KW - Neurotransmitters
KW - Redox cycling
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U2 - 10.1016/j.snb.2019.127245
DO - 10.1016/j.snb.2019.127245
M3 - Article
AN - SCOPUS:85074229974
SN - 0925-4005
VL - 304
JO - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
M1 - 127245
ER -