Reduction of threshold for producing sonodynamic tissue damage by second-harmonic superimposition

Shin ichiro Umemura, Ken ichi Kawabata, Kazuaki Sasaki

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


Induction of acoustic cavitation of progressive waves is known to require much higher ultrasonic intensity than by standing waves. It has been found that acoustic cavitation can be an order of magnitude enhanced by superimposing the second harmonic on the fundamental. Synergistic effects between the fundamental and the second harmonic in the progressive wave mode were investigated using exteriorized mouse livers suspended in degassed saline. The intensity threshold for the production of focal tissue damage paired with fractional harmonic emission was significantly lowered by second-harmonic superimposition especially when a sonochemically active porphyrin had been administered to the mouse. Insonation with second-harmonic superimposition in combination with such a sonochemically active agent may have potential use for selective tumor treatment.

Original languageEnglish
Pages (from-to)1567-1570
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Publication statusPublished - 1995
EventProceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2) - Seattle, WA, USA
Duration: 1995 Nov 71995 Nov 10

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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