Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

W. R. Zhang; T. Hayashi; J. M. Wang; C. Sasaki; K. Sakai; H. Warita; Y. Shiro; H. Suenaga; H. Ohmae; S. Tsuji; T. Itoh; O. Nishimura; H. Nagasaki; K. Abe

doi:10.1016/S0304-3940(99)00848-4

Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

W. R. Zhang, T. Hayashi, J. M. Wang, C. Sasaki, K. Sakai, H. Warita, Y. Shiro, H. Suenaga, H. Ohmae, S. Tsuji, T. Itoh, O. Nishimura, H. Nagasaki, K. Abe

HOSP - Neurological and Psychiatric Disorders

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Abstract

Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 μg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P=0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	161-164
Number of pages	4
Journal	Neuroscience Letters
Volume	276
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(99)00848-4
Publication status	Published - 1999 Dec 10

Keywords

Ischemia
Middle cerebral artery occlusion
Neurotrophin-3
Tyrosine kinase B
Tyrosine kinase C

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10.1016/S0304-3940(99)00848-4

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Zhang, W. R., Hayashi, T., Wang, J. M., Sasaki, C., Sakai, K., Warita, H., Shiro, Y., Suenaga, H., Ohmae, H., Tsuji, S., Itoh, T., Nishimura, O., Nagasaki, H., & Abe, K. (1999). Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat. Neuroscience Letters, 276(3), 161-164. https://doi.org/10.1016/S0304-3940(99)00848-4

@article{203fea69d7864a1ab2388909a5bb98eb,

title = "Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat",

abstract = "Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 μg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P=0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Ischemia, Middle cerebral artery occlusion, Neurotrophin-3, Tyrosine kinase B, Tyrosine kinase C",

author = "Zhang, {W. R.} and T. Hayashi and Wang, {J. M.} and C. Sasaki and K. Sakai and H. Warita and Y. Shiro and H. Suenaga and H. Ohmae and S. Tsuji and T. Itoh and O. Nishimura and H. Nagasaki and K. Abe",

note = "Funding Information: This work was partly supported by Grants-in-Aid for Scientific Research on 09470151 and 10176204 from the Ministry of Education, Japan, Kobayashi Memorial Foundation, Terumo Scientific Foundation, and Takeda Medical Research Foundation.",

year = "1999",

month = dec,

day = "10",

doi = "10.1016/S0304-3940(99)00848-4",

language = "English",

volume = "276",

pages = "161--164",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

Zhang, WR, Hayashi, T, Wang, JM, Sasaki, C, Sakai, K, Warita, H, Shiro, Y, Suenaga, H, Ohmae, H, Tsuji, S, Itoh, T, Nishimura, O, Nagasaki, H & Abe, K 1999, 'Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat', Neuroscience Letters, vol. 276, no. 3, pp. 161-164. https://doi.org/10.1016/S0304-3940(99)00848-4

TY - JOUR

T1 - Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

AU - Zhang, W. R.

AU - Hayashi, T.

AU - Wang, J. M.

AU - Sasaki, C.

AU - Sakai, K.

AU - Warita, H.

AU - Shiro, Y.

AU - Suenaga, H.

AU - Ohmae, H.

AU - Tsuji, S.

AU - Itoh, T.

AU - Nishimura, O.

AU - Nagasaki, H.

AU - Abe, K.

N1 - Funding Information: This work was partly supported by Grants-in-Aid for Scientific Research on 09470151 and 10176204 from the Ministry of Education, Japan, Kobayashi Memorial Foundation, Terumo Scientific Foundation, and Takeda Medical Research Foundation.

PY - 1999/12/10

Y1 - 1999/12/10

N2 - Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 μg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P=0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 μg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P=0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Ischemia

KW - Middle cerebral artery occlusion

KW - Neurotrophin-3

KW - Tyrosine kinase B

KW - Tyrosine kinase C

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U2 - 10.1016/S0304-3940(99)00848-4

DO - 10.1016/S0304-3940(99)00848-4

M3 - Article

C2 - 10612630

AN - SCOPUS:0032694767

SN - 0304-3940

VL - 276

SP - 161

EP - 164

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

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