Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia

Satoshi Horino; Takeshi Rikiishi; Hidetaka Niizuma; Hiroshi Abe; Yuko Watanabe; Masaei Onuma; Yoshiyuki Hoshi; Yoji Sasahara; Miyako Yoshinari; Takuro Kazama; Yutaka Hayashi; Satoru Kumaki; Shigeru Tsuchiya

doi:10.1007/s12185-009-0424-0

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia

Satoshi Horino, Takeshi Rikiishi, Hidetaka Niizuma, Hiroshi Abe, Yuko Watanabe, Masaei Onuma, Yoshiyuki Hoshi, Yoji Sasahara, Miyako Yoshinari, Takuro Kazama, Yutaka Hayashi, Satoru Kumaki, Shigeru Tsuchiya

Tohoku University

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.

Original language	English
Pages (from-to)	483-485
Number of pages	3
Journal	International Journal of Hematology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1007/s12185-009-0424-0
Publication status	Published - 2009

Keywords

Acute lymphoblastic leukemia
GP IIb/IIIa
Immune thrombocytopenic purpura

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10.1007/s12185-009-0424-0

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title = "Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia",

abstract = "Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.",

keywords = "Acute lymphoblastic leukemia, GP IIb/IIIa, Immune thrombocytopenic purpura",

author = "Satoshi Horino and Takeshi Rikiishi and Hidetaka Niizuma and Hiroshi Abe and Yuko Watanabe and Masaei Onuma and Yoshiyuki Hoshi and Yoji Sasahara and Miyako Yoshinari and Takuro Kazama and Yutaka Hayashi and Satoru Kumaki and Shigeru Tsuchiya",

year = "2009",

doi = "10.1007/s12185-009-0424-0",

language = "English",

volume = "90",

pages = "483--485",

journal = "International Journal of Hematology",

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T1 - Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia

AU - Horino, Satoshi

AU - Rikiishi, Takeshi

AU - Niizuma, Hidetaka

AU - Abe, Hiroshi

AU - Watanabe, Yuko

AU - Onuma, Masaei

AU - Hoshi, Yoshiyuki

AU - Sasahara, Yoji

AU - Yoshinari, Miyako

AU - Kazama, Takuro

AU - Hayashi, Yutaka

AU - Kumaki, Satoru

AU - Tsuchiya, Shigeru

PY - 2009

Y1 - 2009

N2 - Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.

AB - Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.

KW - Acute lymphoblastic leukemia

KW - GP IIb/IIIa

KW - Immune thrombocytopenic purpura

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DO - 10.1007/s12185-009-0424-0

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AN - SCOPUS:73449095402

SN - 0925-5710

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SP - 483

EP - 485

JO - International Journal of Hematology

JF - International Journal of Hematology

IS - 4

ER -

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia

Abstract

Keywords

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