Regio- and stereoselective synthesis of multisubstituted enamides by treatment of ynamides with boronic acids

Addition of boronic acids to ynamides can be a useful method to obtain enamides, which have been considered as good prochiral precursors for the synthesis of optically active compounds bearing quaternary stereogenic centers. Although the regioselectivity for carbometalation should be required, recently, highly regio- and stereocontrolled addition reactions have been developed by using transition metal catalysts. In this review, three types of regio- and stereocontrolled synthesis of multisubstituted enamides are discussed.