Regulation of airway responsiveness by dopamine receptor signaling pathways

Kentaro Mizuta

doi:10.1007/978-4-431-54070-0_104

Regulation of airway responsiveness by dopamine receptor signaling pathways

Kentaro Mizuta

DEN - Dental Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

In this chapter, we have demonstrated that dopamine receptor subtypes are expressed on airway smooth muscle (ASM) and modulates ASM function. We detected the expression of dopamine D₁ and D₂ receptors in ASM. Dopamine D₁ receptor agonist stimulated cAMP production in human ASM cells and dose- dependently relaxed guinea pig ASM. Acute activation of the dopamine D₂ receptor in human ASM cells inhibited forskolin-stimulated adenylyl cyclase activity. On the other hand, chronic activation of the dopamine D₂ receptor stimulated it, and potentiated forskolin-induced guinea pig ASM relaxation. These findings suggest that functional dopamine D₁ and D₂ receptors are expressed in ASM, and modulate ASM tone through adenylyl cyclase/cAMP signaling.

Original language	English
Title of host publication	Interface Oral Health Science 2011
Publisher	Springer Japan
Pages	359-361
Number of pages	3
ISBN (Electronic)	9784431540700
ISBN (Print)	9784431540694
DOIs	https://doi.org/10.1007/978-4-431-54070-0_104
Publication status	Published - 2012 Jan 1

Keywords

Adenylyl cyclase
Airway smooth muscle
Asthma
Dopamine

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10.1007/978-4-431-54070-0_104

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abstract = "In this chapter, we have demonstrated that dopamine receptor subtypes are expressed on airway smooth muscle (ASM) and modulates ASM function. We detected the expression of dopamine D1 and D2 receptors in ASM. Dopamine D1 receptor agonist stimulated cAMP production in human ASM cells and dose- dependently relaxed guinea pig ASM. Acute activation of the dopamine D2 receptor in human ASM cells inhibited forskolin-stimulated adenylyl cyclase activity. On the other hand, chronic activation of the dopamine D2 receptor stimulated it, and potentiated forskolin-induced guinea pig ASM relaxation. These findings suggest that functional dopamine D1 and D2 receptors are expressed in ASM, and modulate ASM tone through adenylyl cyclase/cAMP signaling.",

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N2 - In this chapter, we have demonstrated that dopamine receptor subtypes are expressed on airway smooth muscle (ASM) and modulates ASM function. We detected the expression of dopamine D1 and D2 receptors in ASM. Dopamine D1 receptor agonist stimulated cAMP production in human ASM cells and dose- dependently relaxed guinea pig ASM. Acute activation of the dopamine D2 receptor in human ASM cells inhibited forskolin-stimulated adenylyl cyclase activity. On the other hand, chronic activation of the dopamine D2 receptor stimulated it, and potentiated forskolin-induced guinea pig ASM relaxation. These findings suggest that functional dopamine D1 and D2 receptors are expressed in ASM, and modulate ASM tone through adenylyl cyclase/cAMP signaling.

AB - In this chapter, we have demonstrated that dopamine receptor subtypes are expressed on airway smooth muscle (ASM) and modulates ASM function. We detected the expression of dopamine D1 and D2 receptors in ASM. Dopamine D1 receptor agonist stimulated cAMP production in human ASM cells and dose- dependently relaxed guinea pig ASM. Acute activation of the dopamine D2 receptor in human ASM cells inhibited forskolin-stimulated adenylyl cyclase activity. On the other hand, chronic activation of the dopamine D2 receptor stimulated it, and potentiated forskolin-induced guinea pig ASM relaxation. These findings suggest that functional dopamine D1 and D2 receptors are expressed in ASM, and modulate ASM tone through adenylyl cyclase/cAMP signaling.

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KW - Asthma

KW - Dopamine

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Regulation of airway responsiveness by dopamine receptor signaling pathways

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