Regulation of insulin gene transcription

Kinuko Ohneda, Hooi Ee, Michael German

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)


Recent studies of the insulin gene promoter and the transcription factors that regulate it have expanded our understanding of both how the production of insulin is restricted to the pancreatic β-cell, and how that production is regulated by physiologic signals such as glucose. A picture is emerging in which an elaborate set of transcription factors binds to specific sequences along the promoter and recruits additional transcriptional co-activators to build a functional transcriptional activation complex that is unique to β-cells. Surprisingly, however, genetic experiments in mice have demonstrated an unexpected degree of redundancy in the factors that control insulin gene expression, and have revealed the presence of a network of transcription factors that coordinate the expression of factors forming the insulin gene activation complex.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalSeminars in Cell and Developmental Biology
Issue number4
Publication statusPublished - 2000


  • BETA2
  • Glucose
  • Insulin gene
  • NeuroD1
  • Transcription


Dive into the research topics of 'Regulation of insulin gene transcription'. Together they form a unique fingerprint.

Cite this