Regulators of angiogenesis

Endothelial cells lining the lumen of vessels are maintained in the quiescent state and play important physiological roles. Yet, they can be de- differentiated and become one of the most rapidly proliferating of all cell types when stimulated. Angiogenesis or neovascularization is defined as the formation of new capillary vessels from existent microvessels, which plays a major role in the evolvement of a vascular supply in tissue during development or remodeling and disease. Angiogenesis is believed to be regulated by the balance between inducers and inhibitors. In this review article, I will summarize the molecules that regulate the process of angiogenesis.