Relationship between cardiorespiratory fitness and non-high-density lipoprotein cholesterol: A cohort study

Natsumi Watanabe, Susumu S. Sawada, Kazunori Shimada, I. Min Lee, Yuko Gando, Haruki Momma, Ryoko Kawakami, Motohiko Miyachi, Yumiko Hagi, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Steven N. Blair

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Aim: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C.Methods: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986. A cycle ergometer was used to measure the CRF and maximal oxygen uptake was estimated. The incidence of a high level of non-HDL-C (≥170 mg/dL) from 1986 to 2006 was ascertained based on the fasting blood levels. A high level of non-HDL-C was found in 1,482 participants during the follow-up. Cox proportional hazard models were used to obtain the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of a high level of non-HDL-C.Results: Following age adjustment, and using the lowest CRF group (quartileⅠ) as reference, the HRs and 95% CIs for quartiles Ⅱ through Ⅳ were: 1.00 (95% CI: 0.87 –1.15), 0.87 (95% CI: 0.76 –1.00), and 0.70 (95% CI: 0.60 – 0.81), respectively (P for trend0.001). After additional adjustment for body mass index, systolic blood pressure, smoking, alcohol intake, and family history of dyslipidemia, the HRs and 95% CIs were: 1.05 (95% CI: 0.92–1.21), 0.94 (95% CI: 0.81–1.08), and 0.79 (95% CI: 0.67–0.92), respectively (P for trend=0.001).Conclusions: These results suggest that there is an inverse relationship between CRF levels and the incidence of a high level of non-HDL-C in Japanese men.

Original languageEnglish
Pages (from-to)1196-1205
Number of pages10
JournalJournal of Atherosclerosis and Thrombosis
Issue number12
Publication statusPublished - 2018


  • Cholesterol
  • Cohort study
  • Epidemiology
  • Exercise test
  • Non-high-density lipoprotein cholesterol


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