TY - JOUR
T1 - Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients
AU - Matsuda, Yoko
AU - Tanaka, Masashi
AU - Sawabe, Motoji
AU - Mori, Seijiro
AU - Muramatsu, Masaaki
AU - Mieno, Makiko Naka
AU - Furukawa, Toru
AU - Arai, Tomio
N1 - Funding Information:
This work was supported, in part, by a grant from the Smoking Research Foundation to T. Arai, by JSPS KAKENHI Grants (C, No. 16KT0125 to Y. Matsuda, A-16H01872, A-25242062, A-22240072, B-21390459, C-26670481, C-21590411, and CER-24650414 to M. Tanaka), by Grants-in-Aid for Research on Intractable Diseases (Mitochondrial Disorders; 23-016, 23-116, and 24-005 to M. Tanaka), by the Practical Research Project for Rare/ Intractable Diseases Grant from the AMED (15ek0109088h0001 and 15ek0109088s0401 to M. Tanaka), and by the Takeda Science Foundation to M. Tanaka.
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2018/1
Y1 - 2018/1
N2 - We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN-1, −2, −3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.
AB - We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN-1, −2, −3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.
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U2 - 10.1002/gcc.22479
DO - 10.1002/gcc.22479
M3 - Article
C2 - 28639428
AN - SCOPUS:85033212056
SN - 1045-2257
VL - 57
SP - 12
EP - 18
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
IS - 1
ER -
