Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

Yoshitaka Kinouchi; Nobuo Hiwatashi; Seiichi Higashioka; Fumio Nagashima; Masaki Chida; Takayoshi Toyota

doi:10.1016/0304-3835(96)04348-0

Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

Yoshitaka Kinouchi, Nobuo Hiwatashi, Seiichi Higashioka, Fumio Nagashima, Masaki Chida, Takayoshi Toyota

Division of Research in Student Support

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13 informative patients exhibited ROI of IGF2; furthermore, normal mucosa from 3 of these 5 patients also showed weak biallelic expression of IGF2. ROI of IGF2 may thus also play a role in colorectal cancer.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	Cancer Letters
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(96)04348-0
Publication status	Published - 1996 Oct 1

Keywords

Colorectal cancer
Imprinting
Insulin-like growth factor II

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(96)04348-0

Cite this

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title = "Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer",

abstract = "The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13 informative patients exhibited ROI of IGF2; furthermore, normal mucosa from 3 of these 5 patients also showed weak biallelic expression of IGF2. ROI of IGF2 may thus also play a role in colorectal cancer.",

keywords = "Colorectal cancer, Imprinting, Insulin-like growth factor II",

author = "Yoshitaka Kinouchi and Nobuo Hiwatashi and Seiichi Higashioka and Fumio Nagashima and Masaki Chida and Takayoshi Toyota",

note = "Funding Information: Supported in part by a grant-in-aid from the Ministry of Education, Science, and Culture of Japan, and by the Kurokawa Cancer Foundation.",

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T1 - Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

AU - Kinouchi, Yoshitaka

AU - Hiwatashi, Nobuo

AU - Higashioka, Seiichi

AU - Nagashima, Fumio

AU - Chida, Masaki

AU - Toyota, Takayoshi

N1 - Funding Information: Supported in part by a grant-in-aid from the Ministry of Education, Science, and Culture of Japan, and by the Kurokawa Cancer Foundation.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13 informative patients exhibited ROI of IGF2; furthermore, normal mucosa from 3 of these 5 patients also showed weak biallelic expression of IGF2. ROI of IGF2 may thus also play a role in colorectal cancer.

AB - The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13 informative patients exhibited ROI of IGF2; furthermore, normal mucosa from 3 of these 5 patients also showed weak biallelic expression of IGF2. ROI of IGF2 may thus also play a role in colorectal cancer.

KW - Colorectal cancer

KW - Imprinting

KW - Insulin-like growth factor II

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Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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