Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism

Yoshitsugu Iwakura, Sadayoshi Ito, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Masahiro Nezu, Kei Takase, Kazumasa Seiji, Shigeto Ishidoya, Yoichi Arai, Yasuharu Funamizu, Takashi Miki, Yasuhiro Nakamura, Hironobu Sasano, Fumitoshi Satoh

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The renal resistive index (RI) calculated by Doppler ultrasonography has been reported to be correlated with renal structural changes and outcomes in patients with essential hypertension or renal disease. However, little is known about this index in primary aldosteronism. In this prospective study, we examined the utility of this index to predict blood pressure (BP) outcome after adrenalectomy in patients with primary aldosteronism. We studied 94 patients with histopathologically proven aldosteronoma who underwent surgery. Parameters on renal function, including renal flow indices, were examined and followed up for 12 months postoperatively. The renal RI of the main, hilum, and interlobar arteries was significantly higher in patients with aldosteronoma compared with 100 control patients. BP, estimated glomerular filtration rate, and urinary albumin excretion significantly decreased after adrenalectomy. The resistive indices of all compartment arteries were significantly reduced 1 month after adrenalectomy and remained stable for 12 months. Patients whose interlobar RI was in the highest tertile at baseline had higher systolic BP after adrenalectomy than those whose RI was in the lowest tertile. Logistic regression analysis demonstrated that the RI of the interlobar and hilum arteries could be an independent predictive marker for intractable hypertension (systolic BP ≥140 mm Hg, increased BP, taking ≥3 antihypertensive agents, or increased number of agents) even after adrenalectomy. Therefore, in patients with aldosteronoma, the renal RI indicates partially reversible renal hemodynamics and renal structural damages that would influence postoperative BP outcome.

Original languageEnglish
Pages (from-to)654-660
Number of pages7
Issue number3
Publication statusPublished - 2016 Mar 1


  • adrenalectomy
  • blood pressure
  • hyperaldosteronism
  • hypertension
  • ultrasonography, Doppler


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