Repeated injections of nicergoline increase the nerve growth factor level in the aged rat brain

Takeshi Nishio; Nobuhiko Sunohara; Shoei Furukawa; Ichiro Akiguchi; Yukitsuka Kudo

doi:10.1254/jjp.76.321

Repeated injections of nicergoline increase the nerve growth factor level in the aged rat brain

Takeshi Nishio, Nobuhiko Sunohara, Shoei Furukawa, Ichiro Akiguchi, Yukitsuka Kudo

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.

Original language	English
Pages (from-to)	321-323
Number of pages	3
Journal	Japanese Journal of Pharmacology
Volume	76
Issue number	3
DOIs	https://doi.org/10.1254/jjp.76.321
Publication status	Published - 1998 Mar

Keywords

Aged rat brain
Nerve growth factor
Nicergoline

ASJC Scopus subject areas

Pharmacology

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10.1254/jjp.76.321

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abstract = "We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.",

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AU - Furukawa, Shoei

AU - Akiguchi, Ichiro

AU - Kudo, Yukitsuka

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N2 - We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.

AB - We studied whether nicergoline, clinically active in chronic cerebrovascular insufficiency, influences nerve growth factor (NGF) levels in the rat brain. In young Fischer rats, repeated intraperitoneal injections of nicergoline (0.3 and 1.0 mg/kg body weight) did not show any effects on frontal NGF contents determined by a highly sensitive enzyme immunoassay. In aged rats, 22-month-old, however, repeated injections of nicergoline (1.0 mg/kg body weight) induced a significant increase in the NGF level in the frontal region.

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KW - Nerve growth factor

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Repeated injections of nicergoline increase the nerve growth factor level in the aged rat brain

Abstract

Keywords

ASJC Scopus subject areas

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