Reproducibility of PET brain mapping of cancer patients

Manabu Tashiro, Freimut D. Juengling, Michael J. Reinhardt, Ingo Brink, Stefan Hoegerle, Michael Mix, Kazuo Kubota, Keiichiro Yamaguchi, Masatoshi Itoh, Hidetada Sasaki, Ernst Moser, Egbert U. Nitzsche

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Twenty German cancer patients (56.9 ± 12.7 years old) without brain metastasis underwent neurological PET. The acquired brain data were compared to the data of ten age and sex-matched controls (53.6 ± 15.7). Scores of Zung's Self-rating Depression Scale (SDS) obtained from 15 out of the 20 patients suggested they might be mildly depressed. Scores of Taylor's Manifest Anxiety Scale (MAS), used for additional psychological evaluation, were close to normal distribution. Hypometabolic areas in the German cancer patients were compared with those demonstrated in our previous study in Japanese cancer patients. Common findings in both studies were observed in the limbic structures, such as the anterior and posterior cingulate gyri, the basolateral frontal cortices, as well as in the basal ganglia (especially the caudate nucleus) and frontal cortex. These results are in accordance with many previous PET studies on major depression. The results show that the positron emission tomography and 18F-fluoro-deoxyglucose (18FDG-PET) brain mapping results could be partially reproduced, and suggest that PET brain mapping of cancer patients has a potential clinical application to the field of psycho-oncology and cancer patient care. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
Issue number2
Publication statusPublished - 2000 Mar

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Oncology
  • Psychiatry and Mental health


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