Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum

Erina Kuranaga, Hirotaka Kanuka, Yasufumi Furuhata, Tomohiro Yonezawa, Masatoshi Suzuki, Masugi Nishihara, Michio Takahashi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalFEBS Letters
Issue number1
Publication statusPublished - 2000 Apr 21
Externally publishedYes


  • Apoptosis
  • Cell death
  • Fas/Fas ligand
  • Luteal immune cell
  • Luteolysis
  • Rat corpus luteum

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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