Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum

Erina Kuranaga; Hirotaka Kanuka; Yasufumi Furuhata; Tomohiro Yonezawa; Masatoshi Suzuki; Masugi Nishihara; Michio Takahashi

doi:10.1016/S0014-5793(00)01426-5

Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum

Erina Kuranaga, Hirotaka Kanuka, Yasufumi Furuhata, Tomohiro Yonezawa, Masatoshi Suzuki, Masugi Nishihara, Michio Takahashi

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL. Copyright (C) 2000 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	FEBS Letters
Volume	472
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(00)01426-5
Publication status	Published - 2000 Apr 21
Externally published	Yes

Keywords

Apoptosis
Cell death
Fas/Fas ligand
Luteal immune cell
Luteolysis
Rat corpus luteum

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(00)01426-5

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title = "Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum",

abstract = "Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL. Copyright (C) 2000 Federation of European Biochemical Societies.",

keywords = "Apoptosis, Cell death, Fas/Fas ligand, Luteal immune cell, Luteolysis, Rat corpus luteum",

author = "Erina Kuranaga and Hirotaka Kanuka and Yasufumi Furuhata and Tomohiro Yonezawa and Masatoshi Suzuki and Masugi Nishihara and Michio Takahashi",

note = "Funding Information: We are grateful to Dr. Keitaro Yamanouchi (Laboratory of Applied Genetics, Animal Resource Science, The University of Tokyo) for critical reading. This study was supported by {\textquoteleft}Research for the Future{\textquoteright} program of The Japan Society for the Promotion of Science (97L00904). H.K. is a research fellow of the Japan Society for the Promotion of Science. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0014-5793(00)01426-5",

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AU - Kuranaga, Erina

AU - Kanuka, Hirotaka

AU - Furuhata, Yasufumi

AU - Yonezawa, Tomohiro

AU - Suzuki, Masatoshi

AU - Nishihara, Masugi

AU - Takahashi, Michio

N1 - Funding Information: We are grateful to Dr. Keitaro Yamanouchi (Laboratory of Applied Genetics, Animal Resource Science, The University of Tokyo) for critical reading. This study was supported by ‘Research for the Future’ program of The Japan Society for the Promotion of Science (97L00904). H.K. is a research fellow of the Japan Society for the Promotion of Science. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2000/4/21

Y1 - 2000/4/21

N2 - Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL. Copyright (C) 2000 Federation of European Biochemical Societies.

AB - Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL. Copyright (C) 2000 Federation of European Biochemical Societies.

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KW - Luteal immune cell

KW - Luteolysis

KW - Rat corpus luteum

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Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum

Abstract

Keywords

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