NOD-SCID mice orally inoculated with 9 × 109 colony-forming units of Shiga toxin-producing Escherichia coli (STEC) O111 and treated 48 h later with an intravenous injection of 5 × 104 human bone marrow-derived multilineage-differentiating stress-enduring (Muse) cells exhibited 100% survival. Thus, the intravenous administration of Muse cells might be a candidate therapeutic approach for preventing acute encephalopathy after STEC infection.
- acute encephalopathy
- Muse cells
- Shiga toxin-producing Escherichia coli