@article{7e6f5ab182144eae8d5dcc0564ca1da5,
title = "Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice",
abstract = "NOD-SCID mice orally inoculated with 9 × 109 colony-forming units of Shiga toxin-producing Escherichia coli (STEC) O111 and treated 48 h later with an intravenous injection of 5 × 104 human bone marrow-derived multilineage-differentiating stress-enduring (Muse) cells exhibited 100% survival. Thus, the intravenous administration of Muse cells might be a candidate therapeutic approach for preventing acute encephalopathy after STEC infection.",
keywords = "acute encephalopathy, Muse cells, Shiga toxin-producing Escherichia coli",
author = "Ryo Ozuru and Shohei Wakao and Takahiro Tsuji and Naoya Ohara and Takashi Matsuba and Amuran, {Muhammad Y.} and Junko Isobe and Morio Iino and Naoki Nishida and Sari Matsumoto and Kimiharu Iwadate and Noriko Konishi and Kaori Yasuda and Kosuke Tashiro and Misato Hida and Arisato Yadoiwa and Shinsuke Kato and Eijiro Yamashita and Sohkichi Matsumoto and Yoichi Kurozawa and Mari Dezawa and Jun Fujii",
note = "Funding Information: This study was partly funded by the Research Program of the International Platform for Dryland Research and Education, Tottori University , and Yakult Grants for Research on Lactic Acid Bacteria . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Animal Research Facility, Tottori University for mouse care support. We would like to thank Genostaff Co., Ltd., Japan for technical support of immunohistochemistry. This research was partly performed at the Tottori Bio Frontier, managed by Tottori prefecture. We would like to thank Hideki Nakazato (Charles River Laboratories, Japan) for providing NOD-SCID mice to adjust mouse body weight, Mr. Nobuyuki Endo (Keyence, Japan) for technical support of all-in-one microscopy, and Mr. Masato Takiguchi (ZEISS Research, Japan) for technical support of confocal microscopy LSM780. Finally, we thank Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan for providing MMC with free charge. Funding Information: This study was partly funded by the Research Program of the International Platform for Dryland Research and Education, Tottori University, and Yakult Grants for Research on Lactic Acid Bacteria. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Animal Research Facility, Tottori University for mouse care support. We would like to thank Genostaff Co. Ltd. Japan for technical support of immunohistochemistry. This research was partly performed at the Tottori Bio Frontier, managed by Tottori prefecture. We would like to thank Hideki Nakazato (Charles River Laboratories, Japan) for providing NOD-SCID mice to adjust mouse body weight, Mr. Nobuyuki Endo (Keyence, Japan) for technical support of all-in-one microscopy, and Mr. Masato Takiguchi (ZEISS Research, Japan) for technical support of confocal microscopy LSM780. Finally, we thank Kyowa Hakko Kogyo Co. Ltd. Tokyo, Japan for providing MMC with free charge. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2020",
month = jan,
day = "8",
doi = "10.1016/j.ymthe.2019.09.023",
language = "English",
volume = "28",
pages = "100--118",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Cell Press",
number = "1",
}