Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether

Yu Liu; Ying Wei Yang; Yun Song; Heng Yi Zhang; Fei Ding; Takehiko Wada; Yoshihisa Inoue

doi:10.1002/cbic.200300770

Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether

Yu Liu, Ying Wei Yang, Yun Song, Heng Yi Zhang, Fei Ding, Takehiko Wada, Yoshihisa Inoue

IMRAM - Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Do you recognise this peptide? Novel 6,6′-(2,2′-dithio-bis(2- (benzoylamino)ethylamino))-bridged bis(β-CD), such as the one shown here, showed good to excellent residue selectivities of up to 28 for several nonaromatic dipeptides with the complex stability sequence of Glu-Glu < Gly-Gly < Leu-Gly < Met-Met < Gly-Pro < Gly-Leu, and also a high sequence selectivity of 5.0 for Gly-Leu versus Leu-Gly.

Original language	English
Pages (from-to)	868-871
Number of pages	4
Journal	ChemBioChem
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/cbic.200300770
Publication status	Published - 2004 Jun 7

Keywords

Binding
Cyclodextrins
Peptides
Recognition

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10.1002/cbic.200300770

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title = "Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether",

abstract = "Do you recognise this peptide? Novel 6,6′-(2,2′-dithio-bis(2- (benzoylamino)ethylamino))-bridged bis(β-CD), such as the one shown here, showed good to excellent residue selectivities of up to 28 for several nonaromatic dipeptides with the complex stability sequence of Glu-Glu < Gly-Gly < Leu-Gly < Met-Met < Gly-Pro < Gly-Leu, and also a high sequence selectivity of 5.0 for Gly-Leu versus Leu-Gly.",

keywords = "Binding, Cyclodextrins, Peptides, Recognition",

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T1 - Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether

AU - Liu, Yu

AU - Yang, Ying Wei

AU - Song, Yun

AU - Zhang, Heng Yi

AU - Ding, Fei

AU - Wada, Takehiko

AU - Inoue, Yoshihisa

PY - 2004/6/7

Y1 - 2004/6/7

N2 - Do you recognise this peptide? Novel 6,6′-(2,2′-dithio-bis(2- (benzoylamino)ethylamino))-bridged bis(β-CD), such as the one shown here, showed good to excellent residue selectivities of up to 28 for several nonaromatic dipeptides with the complex stability sequence of Glu-Glu < Gly-Gly < Leu-Gly < Met-Met < Gly-Pro < Gly-Leu, and also a high sequence selectivity of 5.0 for Gly-Leu versus Leu-Gly.

AB - Do you recognise this peptide? Novel 6,6′-(2,2′-dithio-bis(2- (benzoylamino)ethylamino))-bridged bis(β-CD), such as the one shown here, showed good to excellent residue selectivities of up to 28 for several nonaromatic dipeptides with the complex stability sequence of Glu-Glu < Gly-Gly < Leu-Gly < Met-Met < Gly-Pro < Gly-Leu, and also a high sequence selectivity of 5.0 for Gly-Leu versus Leu-Gly.

KW - Binding

KW - Cyclodextrins

KW - Peptides

KW - Recognition

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Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether

Abstract

Keywords

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