Retinoid receptors in human esophageal squamous cell carcinoma: Retinoid X receptor as a potent prognostic factor

Fumiyoshi Fujishima, Takashi Suzuki, Yasuhiro Nakamura, Yusuke Taniyama, Katsuhiko Ono, Akira Sugawara, Shukiti Miyazaki, Takuya Moriya, Akira Sato, Susumu Satomi, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Retinoids regulate cell proliferation and differentiation in normal and neoplastic tissue. These effects are mainly mediated by two types of nuclear retinoid receptors, retinoic acid receptors (RAR) and retinoid X receptors (RXR). RXR have been demonstrated to play important roles in esophageal carcinoma, but the expression of RXRβ and RXRγ has not been examined in esophagus. Therefore, we examined the immunoreactivity of all subtypes of RAR and RXR in 53 non-neoplastic esophageal epithelium and 74 esophageal squamous cell carcinoma tissues. In non-neoplastic epithelium RARβ immunoreactivity was marked in the basal layer and weak in the suprabasal layer, but immunoreactivity of other retinoid receptors was detected in both of layers. In addition, the status of RARβ and RXRβ immunoreactivity inversely correlated with that of lymph node metastasis (P= 0.0477 and P= 0.0034, respectively); decreased RXRβ immunoreactivity of carcinoma cells was positively associated with adverse clinical outcome of the patients (P= 0.0187). These findings all indicate the important roles of retinoid receptors, especially, RXR in the esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalPathology international
Issue number7
Publication statusPublished - 2011 Jul


  • Esophageal cancer
  • Immunohistochemistry
  • Metastasis
  • Retinoid receptors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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