TY - JOUR
T1 - Retinoid receptors in human esophageal squamous cell carcinoma
T2 - Retinoid X receptor as a potent prognostic factor
AU - Fujishima, Fumiyoshi
AU - Suzuki, Takashi
AU - Nakamura, Yasuhiro
AU - Taniyama, Yusuke
AU - Ono, Katsuhiko
AU - Sugawara, Akira
AU - Miyazaki, Shukiti
AU - Moriya, Takuya
AU - Sato, Akira
AU - Satomi, Susumu
AU - Sasano, Hironobu
PY - 2011/7
Y1 - 2011/7
N2 - Retinoids regulate cell proliferation and differentiation in normal and neoplastic tissue. These effects are mainly mediated by two types of nuclear retinoid receptors, retinoic acid receptors (RAR) and retinoid X receptors (RXR). RXR have been demonstrated to play important roles in esophageal carcinoma, but the expression of RXRβ and RXRγ has not been examined in esophagus. Therefore, we examined the immunoreactivity of all subtypes of RAR and RXR in 53 non-neoplastic esophageal epithelium and 74 esophageal squamous cell carcinoma tissues. In non-neoplastic epithelium RARβ immunoreactivity was marked in the basal layer and weak in the suprabasal layer, but immunoreactivity of other retinoid receptors was detected in both of layers. In addition, the status of RARβ and RXRβ immunoreactivity inversely correlated with that of lymph node metastasis (P= 0.0477 and P= 0.0034, respectively); decreased RXRβ immunoreactivity of carcinoma cells was positively associated with adverse clinical outcome of the patients (P= 0.0187). These findings all indicate the important roles of retinoid receptors, especially, RXR in the esophageal squamous cell carcinoma.
AB - Retinoids regulate cell proliferation and differentiation in normal and neoplastic tissue. These effects are mainly mediated by two types of nuclear retinoid receptors, retinoic acid receptors (RAR) and retinoid X receptors (RXR). RXR have been demonstrated to play important roles in esophageal carcinoma, but the expression of RXRβ and RXRγ has not been examined in esophagus. Therefore, we examined the immunoreactivity of all subtypes of RAR and RXR in 53 non-neoplastic esophageal epithelium and 74 esophageal squamous cell carcinoma tissues. In non-neoplastic epithelium RARβ immunoreactivity was marked in the basal layer and weak in the suprabasal layer, but immunoreactivity of other retinoid receptors was detected in both of layers. In addition, the status of RARβ and RXRβ immunoreactivity inversely correlated with that of lymph node metastasis (P= 0.0477 and P= 0.0034, respectively); decreased RXRβ immunoreactivity of carcinoma cells was positively associated with adverse clinical outcome of the patients (P= 0.0187). These findings all indicate the important roles of retinoid receptors, especially, RXR in the esophageal squamous cell carcinoma.
KW - Esophageal cancer
KW - Immunohistochemistry
KW - Metastasis
KW - Retinoid receptors
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U2 - 10.1111/j.1440-1827.2011.02674.x
DO - 10.1111/j.1440-1827.2011.02674.x
M3 - Article
C2 - 21707843
AN - SCOPUS:79959679515
SN - 1320-5463
VL - 61
SP - 401
EP - 408
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
IS - 7
ER -
