Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery

Taku Fujimura; Kazuhiro Takahashi; Yumi Kambayashi; Sadanori Furudate; Takanori Hidaka; Aya Kakizaki; Akiko Watabe; Takahiro Haga; Akira Hashimoto; Setsuya Aiba

doi:10.21873/anticanres.11526

Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery

Taku Fujimura, Kazuhiro Takahashi, Yumi Kambayashi, Sadanori Furudate, Takanori Hidaka, Aya Kakizaki, Akiko Watabe, Takahiro Haga, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: Continuous intra-arterial (IA) administration of peplomycin (PEP) through a tumor-feeding artery is one of the most effective treatments for cutaneous squamous cell carcinoma (cSCC) in cosmetic areas. Patients and Methods: In order to determine the effective and safe dose of PEP and the curative rate of IA-PEP, we retrospectively investigated a case series of 24 patients with cSCC on the lips who were treated with IA-PEP. Results: IA-PEP reduced the tumor mass in all 24 cases (100%). A complete response occurred in 17 patients (70.8%), and a partial response occurred in seven (29.2%). Moreover, 17 patients (70.8%) were cured, three patients developed cervical lymph node metastasis (12.5%), and four developed local recurrence (16.7%). Three out of the 24 patients developed interstitial pneumonia (12.5%). Conclusion: Low-dose IA-PEP administered through a superficial temporal artery was a highly effective treatment that achieved a curative response for 70.8% of patients with cSCC on the lips.

Original language	English
Pages (from-to)	1885-1889
Number of pages	5
Journal	Anticancer Research
Volume	37
Issue number	4
DOIs	https://doi.org/10.21873/anticanres.11526
Publication status	Published - 2017 Apr

Keywords

Continuous intra-arterial administration
Curative response
Cutaneous SCC on the lip
Interstitial pneumonia
Peplomycin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.11526

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Fujimura, T., Takahashi, K., Kambayashi, Y., Furudate, S., Hidaka, T., Kakizaki, A., Watabe, A., Haga, T., Hashimoto, A., & Aiba, S. (2017). Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery. Anticancer Research, 37(4), 1885-1889. https://doi.org/10.21873/anticanres.11526

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title = "Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery",

abstract = "Background: Continuous intra-arterial (IA) administration of peplomycin (PEP) through a tumor-feeding artery is one of the most effective treatments for cutaneous squamous cell carcinoma (cSCC) in cosmetic areas. Patients and Methods: In order to determine the effective and safe dose of PEP and the curative rate of IA-PEP, we retrospectively investigated a case series of 24 patients with cSCC on the lips who were treated with IA-PEP. Results: IA-PEP reduced the tumor mass in all 24 cases (100%). A complete response occurred in 17 patients (70.8%), and a partial response occurred in seven (29.2%). Moreover, 17 patients (70.8%) were cured, three patients developed cervical lymph node metastasis (12.5%), and four developed local recurrence (16.7%). Three out of the 24 patients developed interstitial pneumonia (12.5%). Conclusion: Low-dose IA-PEP administered through a superficial temporal artery was a highly effective treatment that achieved a curative response for 70.8% of patients with cSCC on the lips.",

keywords = "Continuous intra-arterial administration, Curative response, Cutaneous SCC on the lip, Interstitial pneumonia, Peplomycin",

author = "Taku Fujimura and Kazuhiro Takahashi and Yumi Kambayashi and Sadanori Furudate and Takanori Hidaka and Aya Kakizaki and Akiko Watabe and Takahiro Haga and Akira Hashimoto and Setsuya Aiba",

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Fujimura, T, Takahashi, K, Kambayashi, Y, Furudate, S, Hidaka, T, Kakizaki, A, Watabe, A, Haga, T, Hashimoto, A & Aiba, S 2017, 'Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery', Anticancer Research, vol. 37, no. 4, pp. 1885-1889. https://doi.org/10.21873/anticanres.11526

TY - JOUR

T1 - Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery

AU - Fujimura, Taku

AU - Takahashi, Kazuhiro

AU - Kambayashi, Yumi

AU - Furudate, Sadanori

AU - Hidaka, Takanori

AU - Kakizaki, Aya

AU - Watabe, Akiko

AU - Haga, Takahiro

AU - Hashimoto, Akira

AU - Aiba, Setsuya

PY - 2017/4

Y1 - 2017/4

N2 - Background: Continuous intra-arterial (IA) administration of peplomycin (PEP) through a tumor-feeding artery is one of the most effective treatments for cutaneous squamous cell carcinoma (cSCC) in cosmetic areas. Patients and Methods: In order to determine the effective and safe dose of PEP and the curative rate of IA-PEP, we retrospectively investigated a case series of 24 patients with cSCC on the lips who were treated with IA-PEP. Results: IA-PEP reduced the tumor mass in all 24 cases (100%). A complete response occurred in 17 patients (70.8%), and a partial response occurred in seven (29.2%). Moreover, 17 patients (70.8%) were cured, three patients developed cervical lymph node metastasis (12.5%), and four developed local recurrence (16.7%). Three out of the 24 patients developed interstitial pneumonia (12.5%). Conclusion: Low-dose IA-PEP administered through a superficial temporal artery was a highly effective treatment that achieved a curative response for 70.8% of patients with cSCC on the lips.

AB - Background: Continuous intra-arterial (IA) administration of peplomycin (PEP) through a tumor-feeding artery is one of the most effective treatments for cutaneous squamous cell carcinoma (cSCC) in cosmetic areas. Patients and Methods: In order to determine the effective and safe dose of PEP and the curative rate of IA-PEP, we retrospectively investigated a case series of 24 patients with cSCC on the lips who were treated with IA-PEP. Results: IA-PEP reduced the tumor mass in all 24 cases (100%). A complete response occurred in 17 patients (70.8%), and a partial response occurred in seven (29.2%). Moreover, 17 patients (70.8%) were cured, three patients developed cervical lymph node metastasis (12.5%), and four developed local recurrence (16.7%). Three out of the 24 patients developed interstitial pneumonia (12.5%). Conclusion: Low-dose IA-PEP administered through a superficial temporal artery was a highly effective treatment that achieved a curative response for 70.8% of patients with cSCC on the lips.

KW - Continuous intra-arterial administration

KW - Curative response

KW - Cutaneous SCC on the lip

KW - Interstitial pneumonia

KW - Peplomycin

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Retrospective investigation of cutaneous squamous cell carcinoma on the lip treated with peplomycin administered through a superficial temporal artery

Abstract

Keywords

UN SDGs

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