Reversible effect of lidocaine on raft formation

Kotoe Kamata, Sumie Manno, Yuichi Takakuwa, Makoto Ozaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Lipid rafts have been implicated in the signaling processes. Anesthesia has been postulated to represent a transient, drug-induced interruption of signal transduction. In examining the effects of lidocaine on lipid rafts, we found that the agent abolished raft formation in a reversible manner in an erythrocyte membrane model. Our results suggested that raft-related signal transduction is involved in the anesthetic mechanism.

Original languageEnglish
Pages (from-to)281-282
Number of pages2
JournalInternational Congress Series
Publication statusPublished - 2005 Nov


  • Erythrocyte
  • Flotillin-1
  • Lidocaine hydrochloride
  • Raft


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