Reversible effect of lidocaine on raft formation

Kotoe Kamata; Sumie Manno; Yuichi Takakuwa; Makoto Ozaki

doi:10.1016/j.ics.2005.06.077

Reversible effect of lidocaine on raft formation

Kotoe Kamata, Sumie Manno, Yuichi Takakuwa, Makoto Ozaki

HOSP - Special Clinical Facilities

Tokyo Women's Medical University

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Lipid rafts have been implicated in the signaling processes. Anesthesia has been postulated to represent a transient, drug-induced interruption of signal transduction. In examining the effects of lidocaine on lipid rafts, we found that the agent abolished raft formation in a reversible manner in an erythrocyte membrane model. Our results suggested that raft-related signal transduction is involved in the anesthetic mechanism.

Original language	English
Pages (from-to)	281-282
Number of pages	2
Journal	International Congress Series
Volume	1283
DOIs	https://doi.org/10.1016/j.ics.2005.06.077
Publication status	Published - 2005 Nov

Keywords

Erythrocyte
Flotillin-1
Lidocaine hydrochloride
Raft

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10.1016/j.ics.2005.06.077

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title = "Reversible effect of lidocaine on raft formation",

abstract = "Lipid rafts have been implicated in the signaling processes. Anesthesia has been postulated to represent a transient, drug-induced interruption of signal transduction. In examining the effects of lidocaine on lipid rafts, we found that the agent abolished raft formation in a reversible manner in an erythrocyte membrane model. Our results suggested that raft-related signal transduction is involved in the anesthetic mechanism.",

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author = "Kotoe Kamata and Sumie Manno and Yuichi Takakuwa and Makoto Ozaki",

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AU - Kamata, Kotoe

AU - Manno, Sumie

AU - Takakuwa, Yuichi

AU - Ozaki, Makoto

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AB - Lipid rafts have been implicated in the signaling processes. Anesthesia has been postulated to represent a transient, drug-induced interruption of signal transduction. In examining the effects of lidocaine on lipid rafts, we found that the agent abolished raft formation in a reversible manner in an erythrocyte membrane model. Our results suggested that raft-related signal transduction is involved in the anesthetic mechanism.

KW - Erythrocyte

KW - Flotillin-1

KW - Lidocaine hydrochloride

KW - Raft

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SP - 281

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JO - International Congress Series

JF - International Congress Series

ER -

Reversible effect of lidocaine on raft formation

Abstract

Keywords

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