Rhinorrhea in Parkinson's disease: A consecutive multicenter study in Japan

Osamu Kano, Masayuki Yoshioka, Hiroshi Nagayama, Shinsuke Hamada, Tetsuya Maeda, Takafumi Hasegawa, Taro Kadowaki, Renpei Sengoku, Hiroo Terashi, Taku Hatano, Nobuatsu Nomoto, Manabu Inoue, Hideki Shimura, Tatsuya Takahashi, Tsuyoshi Uchiyama, Hirohisa Watanabe, Satoshi Kaneko, Tetsuya Takahashi, Yasuhiko Baba, Shin Ichiro Kubo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Recent reports suggest that rhinorrhea, defined as the presence of a runny nose unrelated to respiratory infections, allergies, or sinus problems, occurs more frequently among patients with Parkinson's disease (PD) than among healthy controls. We conducted a questionnaire survey in a multicenter study throughout Japan and compared the frequency of rhinorrhea between 231 PD and 187 normal control (NC) subjects. After excluding patients with rhinitis or paranasal sinusitis, a total of 159 PD and 59 NC subjects were included in our analysis. Rhinorrhea occurred more frequently in PD patients than NC subjects (33.3% vs. 11.9%; P = 0.01). Among PD patients, rhinorrhea was more common in men than women (P = 0.005). Rhinorrhea was not correlated with disease duration, modified Hoehn and Yahr score, disease type (akinesia rigidity vs. tremor dominant), or cardiac sympathetic function (evaluated by 123I- metaiodobenzylguanidine uptake). To our knowledge, this is the first multicenter study on the frequency of PD-related rhinorrhea in Asian countries.

Original languageEnglish
Pages (from-to)88-90
Number of pages3
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - 2014 Aug 15


  • Non-motor symptoms
  • Olfactory dysfunction
  • Parkinson's disease
  • Rhinorrhea
  • Sinusitis


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