TY - CHAP
T1 - Risk of neurodevelopmental disease by paternal aging
T2 - A possible influence of epigenetic alteration in sperm
AU - Kimura, Ryuichi
AU - Yoshizaki, Kaichi
AU - Osumi, Noriko
N1 - Funding Information:
Acknowledgement This work was supported by Grant-in-Aid from MEXT (16H06530).
Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2018.
PY - 2018
Y1 - 2018
N2 - Sincethe theory of DOHaD has been thrown in the spotlight, most attention has focused on environmental effects of the uterus on developing embryos/fetuses. However, the ontogenesis traces back to gametogenesis. Compared to oogenesis, spermatogenesis goes through far more cell divisions and is therefore more prone to genetic variation and epigenetic alterations. This article will mainly discuss recent findings about the effects of the advanced paternal age on the next generation, in relation to the onset of psychiatric disorders such as autism spectrum disorder. We would like to advocate for further exploration on the DOHaD theory in a wider view.
AB - Sincethe theory of DOHaD has been thrown in the spotlight, most attention has focused on environmental effects of the uterus on developing embryos/fetuses. However, the ontogenesis traces back to gametogenesis. Compared to oogenesis, spermatogenesis goes through far more cell divisions and is therefore more prone to genetic variation and epigenetic alterations. This article will mainly discuss recent findings about the effects of the advanced paternal age on the next generation, in relation to the onset of psychiatric disorders such as autism spectrum disorder. We would like to advocate for further exploration on the DOHaD theory in a wider view.
KW - Neurodevelopmental disorder
KW - Paternal aging
KW - Sperm epigenetics
UR - http://www.scopus.com/inward/record.url?scp=85049323525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049323525&partnerID=8YFLogxK
U2 - 10.1007/978-981-10-5526-3_8
DO - 10.1007/978-981-10-5526-3_8
M3 - Chapter
C2 - 29956196
AN - SCOPUS:85049323525
T3 - Advances in Experimental Medicine and Biology
SP - 75
EP - 81
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -