Abstract
A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/lysine and alpha-PRNA/arginine sequences, where the lysine or arginine residue are expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between basic amino acid side-chain groups and DNA's phosphate anions on the backbone. These alpha-PRNAs form stable sequence-specific complex with the complementary DNA.
Original language | English |
---|---|
Pages (from-to) | 75-76 |
Number of pages | 2 |
Journal | Nucleic acids symposium series (2004) |
Issue number | 50 |
DOIs | |
Publication status | Published - 2006 |