Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers

Shinichi Fukushige; Akira Horii

doi:10.1016/j.canlet.2012.03.022

Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers

Shinichi Fukushige, Akira Horii

MED - Medical Sciences

Research output: Contribution to journal › Review article › peer-review

33 Citations (Scopus)

Abstract

The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on therapeutic intervention. Deeper genomic sequencing analyses of pancreatic cancers revealed 12 core pathways and a long duration, nearly 20. years from initiation to distant metastases. This evidence will offer a broader aspect and time window of opportunity for early detection, thus preventing deaths from this cruel cancer. Epigenetic biomarkers can be utilized for assessing cancer risk, early detection, and predicting prognosis and therapeutic responses. In this review, we briefly summarize relevant issues associated with pancreatic cancer progression and recent advances in epigenetic biomarkers such as DNA methylation, miRNAs, satellite repeats, and histone modifications for early diagnosis.

Original language	English
Pages (from-to)	231-237
Number of pages	7
Journal	Cancer Letters
Volume	342
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.03.022
Publication status	Published - 2014 Jan 28

Keywords

DNA methylation
Early detection
MiRNA
Pancreatic cancer
Satellite repeats

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.03.022

Cite this

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title = "Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers",

abstract = "The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on therapeutic intervention. Deeper genomic sequencing analyses of pancreatic cancers revealed 12 core pathways and a long duration, nearly 20. years from initiation to distant metastases. This evidence will offer a broader aspect and time window of opportunity for early detection, thus preventing deaths from this cruel cancer. Epigenetic biomarkers can be utilized for assessing cancer risk, early detection, and predicting prognosis and therapeutic responses. In this review, we briefly summarize relevant issues associated with pancreatic cancer progression and recent advances in epigenetic biomarkers such as DNA methylation, miRNAs, satellite repeats, and histone modifications for early diagnosis.",

keywords = "DNA methylation, Early detection, MiRNA, Pancreatic cancer, Satellite repeats",

author = "Shinichi Fukushige and Akira Horii",

note = "Funding Information: We are grateful to Dr. B.L.S. Pierce (University of Maryland University College) for editorial work in the preparation of this manuscript. This work was supported by a Grant-in Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS). ",

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T2 - Attempts to utilize epigenetic biomarkers

AU - Fukushige, Shinichi

AU - Horii, Akira

N1 - Funding Information: We are grateful to Dr. B.L.S. Pierce (University of Maryland University College) for editorial work in the preparation of this manuscript. This work was supported by a Grant-in Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS).

PY - 2014/1/28

Y1 - 2014/1/28

N2 - The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on therapeutic intervention. Deeper genomic sequencing analyses of pancreatic cancers revealed 12 core pathways and a long duration, nearly 20. years from initiation to distant metastases. This evidence will offer a broader aspect and time window of opportunity for early detection, thus preventing deaths from this cruel cancer. Epigenetic biomarkers can be utilized for assessing cancer risk, early detection, and predicting prognosis and therapeutic responses. In this review, we briefly summarize relevant issues associated with pancreatic cancer progression and recent advances in epigenetic biomarkers such as DNA methylation, miRNAs, satellite repeats, and histone modifications for early diagnosis.

AB - The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on therapeutic intervention. Deeper genomic sequencing analyses of pancreatic cancers revealed 12 core pathways and a long duration, nearly 20. years from initiation to distant metastases. This evidence will offer a broader aspect and time window of opportunity for early detection, thus preventing deaths from this cruel cancer. Epigenetic biomarkers can be utilized for assessing cancer risk, early detection, and predicting prognosis and therapeutic responses. In this review, we briefly summarize relevant issues associated with pancreatic cancer progression and recent advances in epigenetic biomarkers such as DNA methylation, miRNAs, satellite repeats, and histone modifications for early diagnosis.

KW - DNA methylation

KW - Early detection

KW - MiRNA

KW - Pancreatic cancer

KW - Satellite repeats

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DO - 10.1016/j.canlet.2012.03.022

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VL - 342

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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