Role of a transcription factor Pax6 in the developing vertebrate olfactory system

Tadashi Nomura, Hasumi Haba, Noriko Osumi

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)


The olfactory system is responsible for capturing and processing odorant information, which significantly influences a variety of behaviors in animals. The vertebrate olfactory system consists of several neuronal components including the olfactory epithelium, olfactory bulb and olfactory cortex, which originate from distinct embryonic tissues. The transcription factor Pax6 is strongly expressed in the embryonic and postnatal olfactory systems, and regulates neuronal specification, migration and differentiation. Here we review classical and recent studies focusing on the role of Pax6 in the developing olfactory system, and highlight the cellular and molecular mechanisms underlying the highly coordinated developmental processes of the vertebrate olfactory system.

Original languageEnglish
Pages (from-to)683-690
Number of pages8
JournalDevelopment Growth and Differentiation
Issue number9
Publication statusPublished - 2007 Dec


  • Neurogenesis
  • Neuronal migration
  • Olfactory system
  • Pax6
  • fgf


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