Role of histone methylation and demethylation in adipogenesis and obesity

Masashi Okamura, Takeshi Inagaki, Toshiya Tanaka, Juro Sakai

Research output: Contribution to journalReview articlepeer-review

88 Citations (Scopus)


Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARγ targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and storage. Among such modification enzymes are histone lysine methyltransferases, which play important roles in transcriptional regulation. Histone methyltransferases are involved in PPARγ gene expression and subsequent adipogenesis. In addition, recent studies revealed that demethylation of histone H3 at lys9 is associated with resistance to obesity. We here review the role of histone methylation and demethylation in adipogenesis, metabolism and obesity.

Original languageEnglish
Pages (from-to)24-32
Number of pages9
Issue number1
Publication statusPublished - 2010


  • Adipogenesis
  • Epigenetics
  • Histone lysine methyltransferase (HKMT)
  • Metabolic syndrome
  • Obesity
  • PR-Set7
  • Peroxisome proliferator-activated receptor (PPAR)
  • Setd8
  • Setdb1
  • Wnt


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