Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: In vivo and in vitro studies

Frederick Beer; Chuan Hui Kuo; Kei Morohoshi; James Goodliffe; Peter Munro; Cho Cho Aye; Maria Dawson; Ricardo M. Richardson; Limei H. Jones; Yoshifumi Ikeda; Takao Nakamura; Masako Toda; Tom Flynn; Masaharu Ohbayashi; Dai Miyazaki; Santa Jeremy Ono

doi:10.1111/j.1600-065X.2007.00521.x

Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: In vivo and in vitro studies

Frederick Beer, Chuan Hui Kuo, Kei Morohoshi, James Goodliffe, Peter Munro, Cho Cho Aye, Maria Dawson, Ricardo M. Richardson, Limei H. Jones, Yoshifumi Ikeda, Takao Nakamura, Masako Toda, Tom Flynn, Masaharu Ohbayashi, Dai Miyazaki, Santa Jeremy Ono

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that β-chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen-driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that FcεRI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.

Original language	English
Pages (from-to)	96-104
Number of pages	9
Journal	Immunological Reviews
Volume	217
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-065X.2007.00521.x
Publication status	Published - 2007 Jun 1
Externally published	Yes

Keywords

Chemokines
Mast cells
Signal transduction

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/j.1600-065X.2007.00521.x

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Beer, F., Kuo, C. H., Morohoshi, K., Goodliffe, J., Munro, P., Aye, C. C., Dawson, M., Richardson, R. M., Jones, L. H., Ikeda, Y., Nakamura, T., Toda, M., Flynn, T., Ohbayashi, M., Miyazaki, D., & Ono, S. J. (2007). Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: In vivo and in vitro studies. Immunological Reviews, 217(1), 96-104. https://doi.org/10.1111/j.1600-065X.2007.00521.x

Beer, F, Kuo, CH, Morohoshi, K, Goodliffe, J, Munro, P, Aye, CC, Dawson, M, Richardson, RM, Jones, LH, Ikeda, Y, Nakamura, T, Toda, M, Flynn, T, Ohbayashi, M, Miyazaki, D & Ono, SJ 2007, 'Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: In vivo and in vitro studies', Immunological Reviews, vol. 217, no. 1, pp. 96-104. https://doi.org/10.1111/j.1600-065X.2007.00521.x

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abstract = "Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that β-chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen-driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that FcεRI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.",

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AU - Kuo, Chuan Hui

AU - Morohoshi, Kei

AU - Goodliffe, James

AU - Munro, Peter

AU - Aye, Cho Cho

AU - Dawson, Maria

AU - Richardson, Ricardo M.

AU - Jones, Limei H.

AU - Ikeda, Yoshifumi

AU - Nakamura, Takao

AU - Toda, Masako

AU - Flynn, Tom

AU - Ohbayashi, Masaharu

AU - Miyazaki, Dai

AU - Ono, Santa Jeremy

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AB - Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that β-chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen-driven inflammatory response. These data stem from in vivo, ex vivo, and in vitro studies. Data are also presented that suggest that FcεRI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.

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KW - Mast cells

KW - Signal transduction

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Role of β-chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: In vivo and in vitro studies

Abstract

Keywords

ASJC Scopus subject areas

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