TY - JOUR
T1 - Roles of Fc receptors in autoimmunity
AU - Takai, Toshiyuki
N1 - Funding Information:
I would like to thank T. Kurosaki for critical reading of the manuscript and helpful discussion, and N. Tsuchiya and C. Kyogoku for sharing of unpublished data. This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and from the CREST Programme of Japan Science and Technology Corporation.
PY - 2002/8
Y1 - 2002/8
N2 - The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular branches of the immune system, and they have important functions in the activation and down-modulation of immune responses. Balanced signalling through activating and inhibitory FcRs regulates the activity of various cells in the immune system. Recent work in animal models indicates that the development of many human autoimmune diseases might be caused by impairment of the FcR regulatory system. This review provides an overview of the mechanisms of FcR-based immune regulation and describes how autoimmune disease might result from its dysfunction.
AB - The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular branches of the immune system, and they have important functions in the activation and down-modulation of immune responses. Balanced signalling through activating and inhibitory FcRs regulates the activity of various cells in the immune system. Recent work in animal models indicates that the development of many human autoimmune diseases might be caused by impairment of the FcR regulatory system. This review provides an overview of the mechanisms of FcR-based immune regulation and describes how autoimmune disease might result from its dysfunction.
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U2 - 10.1038/nri856
DO - 10.1038/nri856
M3 - Review article
C2 - 12154377
AN - SCOPUS:0036676975
SN - 1474-1733
VL - 2
SP - 580
EP - 592
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 8
ER -
