S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

Yuefeng Huang, Kairui Mao, Xi Chen, Ming An Sun, Takeshi Kawabe, Weizhe Li, Nicholas Usher, Jinfang Zhu, Joseph F. Urban, William E. Paul, Ronald N. Germain

Research output: Contribution to journalArticlepeer-review

352 Citations (Scopus)


Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have been considered to be tissue-resident cells, but whether ILCs move between tissue sites during infection has been unclear.We show here that interleukin-25-or helminth-induced inflammatory ILC2s are circulating cells that arise from resting ILC2s residing in intestinal lamina propria. They migrate to diverse tissues based on sphingosine 1-phosphate (S1P)-mediated chemotaxis that promotes lymphatic entry, blood circulation, and accumulation in peripheral sites, including the lung, where they contribute to anti-helminth defense and tissue repair.This ILC2 expansion and migration is a behavioral parallel to the antigen-driven proliferation and migration of adaptive lymphocytes to effector sites and indicates that ILCs complement adaptive immunity by providing both local and distant tissue protection during infection.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
Issue number6371
Publication statusPublished - 2018 Jan 5


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