Safety and efficacy of imidapril in the treatment of essential hypertension

Masashi Okamura, Susumu Ogawa, Sadayoshi Ito

Research output: Contribution to journalReview articlepeer-review


Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are one of the renin angio-tensin system (RAS) inhibitors widely used for the treatment of hypertension. Recently, Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC) meta-analysis showed that ACEIs had the blood pressure independent beneficial effects on coronary heart events. In this review, we summarized our current knowledge about ACEIs especially imidapril and re-evaluated ACEIs among other RAS inhibitors (RASIs) because ACEIs have wide ranges of beneficial effects in addition to the ACE inhibition which other RASIs do not have such as the up-regulation of bradykinin level, substance P level, the inhibition of matrix metalloproteinase (MMP) activity and stabilization of coronary plaque.

Original languageEnglish
Pages (from-to)477-486
Number of pages10
JournalClinical Medicine Insights: Therapeutics
Publication statusPublished - 2011


  • Angiotensin
  • Blood pressure lowering treatment trialists' collaboration
  • Diabetic nephropathy
  • Hypertension
  • Imidapril
  • Imidaprilat


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