Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective

Michal T. Krauze, Scott R. Vandenberg, Yoji Yamashita, Ryuta Saito, John Forsayeth, Charles Noble, John Park, Krystof S. Bankiewicz

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Convection-enhanced delivery (CED) is gaining popularity in direct brain infusions. Our group has pioneered the use of liposomes loaded with the MRI contrast reagent as a means to track and quantitate CED in the primate brain through real-time MRI. When co-infused with therapeutic nanoparticles, these tracking liposomes provide us with unprecedented precision in the management of infusions into discrete brain regions. In order to translate real-time CED into clinical application, several important parameters must be defined. In this study, we have analyzed all our cumulative animal data to answer a number of questions as to whether real-time CED in primates depends on concentration of infusate, is reproducible, allows prediction of distribution in a given anatomic structure, and whether it has long term pathological consequences. Our retrospective analysis indicates that real-time CED is highly predictable; repeated procedures yielded identical results, and no long-term brain pathologies were found. We conclude that introduction of our technique to clinical application would enhance accuracy and patient safety when compared to current non-monitored delivery trials.

Original languageEnglish
Pages (from-to)638-644
Number of pages7
JournalExperimental Neurology
Issue number2
Publication statusPublished - 2008 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


Dive into the research topics of 'Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective'. Together they form a unique fingerprint.

Cite this