Scanning electrochemical microscopy for biosurface imaging

Yuanshu Zhou, Yasufumi Takahashi, Takeshi Fukuma, Tomokazu Matsue

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Scanning electrochemical microscopy (SECM) is a powerful technique that can provide chemical identity, quantification, and spatiotemporal information on biosurfaces. The ability of SECM for noninvasive and high-resolution electrochemical imaging has made it valuable for the study of cell phenotypes and functions. This review focuses on the latest advances of SECM technique for the biosurface imaging. The SECM measurements of different biomarkers, including oxygen consumption rate and enzyme activity of cell aggregates, redox state of cardiomyocytes, and bacterial metabolic activity, are introduced. The applicability of SECM on membrane permeability measurements, neurotransmitter measurements, and intracellular measurements is discussed.

Original languageEnglish
Article number100739
JournalCurrent Opinion in Electrochemistry
Publication statusPublished - 2021 Oct


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