TY - JOUR
T1 - Scanning electrochemical microscopy for biosurface imaging
AU - Zhou, Yuanshu
AU - Takahashi, Yasufumi
AU - Fukuma, Takeshi
AU - Matsue, Tomokazu
N1 - Funding Information:
This work was supported by World Premier International Research Center Initiative (WPI) from MEXT, Japan and a Grant-in-Aid for Young Scientists ( 19K15601 ) from the Japan Society for the Promotion of Science (JSPS) .
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/10
Y1 - 2021/10
N2 - Scanning electrochemical microscopy (SECM) is a powerful technique that can provide chemical identity, quantification, and spatiotemporal information on biosurfaces. The ability of SECM for noninvasive and high-resolution electrochemical imaging has made it valuable for the study of cell phenotypes and functions. This review focuses on the latest advances of SECM technique for the biosurface imaging. The SECM measurements of different biomarkers, including oxygen consumption rate and enzyme activity of cell aggregates, redox state of cardiomyocytes, and bacterial metabolic activity, are introduced. The applicability of SECM on membrane permeability measurements, neurotransmitter measurements, and intracellular measurements is discussed.
AB - Scanning electrochemical microscopy (SECM) is a powerful technique that can provide chemical identity, quantification, and spatiotemporal information on biosurfaces. The ability of SECM for noninvasive and high-resolution electrochemical imaging has made it valuable for the study of cell phenotypes and functions. This review focuses on the latest advances of SECM technique for the biosurface imaging. The SECM measurements of different biomarkers, including oxygen consumption rate and enzyme activity of cell aggregates, redox state of cardiomyocytes, and bacterial metabolic activity, are introduced. The applicability of SECM on membrane permeability measurements, neurotransmitter measurements, and intracellular measurements is discussed.
UR - http://www.scopus.com/inward/record.url?scp=85105081686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105081686&partnerID=8YFLogxK
U2 - 10.1016/j.coelec.2021.100739
DO - 10.1016/j.coelec.2021.100739
M3 - Review article
AN - SCOPUS:85105081686
SN - 2451-9103
VL - 29
JO - Current Opinion in Electrochemistry
JF - Current Opinion in Electrochemistry
M1 - 100739
ER -