TY - JOUR
T1 - Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development
AU - Sugimoto, Asako
AU - Iino, Yuichi
AU - Maeda, Tatsuya
AU - Watanabe, Yoshinori
AU - Yamamoto, Masayuki
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1991/11
Y1 - 1991/11
N2 - Schizosaccharomyces pombe ste11 encodes a member of the family of HMG-box proteins. Its transcript is induced in response to nitrogen starvation and a concomitant decrease of the intracellular cAMP level. Expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation. Ste11 protein regulates positively transcription of the following genes required for sexual development: the mating type genes, matP and matM, and the mei2 gene, which is essential for commitment to meiosis. Ste11 protein synthesized in vitro binds specifically to a DNA fragment carrying a 10-base motif TTCTTTGTTY that is an essential cis-acting element for the induction of mei2 and is commonly seen in the upstream regions of the genes inducible by nitrogen starvation. These observations strongly suggest that Ste11 serves as a key transcription factor for sexual development.
AB - Schizosaccharomyces pombe ste11 encodes a member of the family of HMG-box proteins. Its transcript is induced in response to nitrogen starvation and a concomitant decrease of the intracellular cAMP level. Expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation. Ste11 protein regulates positively transcription of the following genes required for sexual development: the mating type genes, matP and matM, and the mei2 gene, which is essential for commitment to meiosis. Ste11 protein synthesized in vitro binds specifically to a DNA fragment carrying a 10-base motif TTCTTTGTTY that is an essential cis-acting element for the induction of mei2 and is commonly seen in the upstream regions of the genes inducible by nitrogen starvation. These observations strongly suggest that Ste11 serves as a key transcription factor for sexual development.
KW - DNA-binding activity
KW - High-mobility group protein box
KW - Nitrogen starvation
KW - Schizosaccharomyces pombe
KW - Sexual differentiation
KW - Transcription factor
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U2 - 10.1101/gad.5.11.1990
DO - 10.1101/gad.5.11.1990
M3 - Article
C2 - 1657709
AN - SCOPUS:0026038558
SN - 0890-9369
VL - 5
SP - 1990
EP - 1999
JO - Genes and Development
JF - Genes and Development
IS - 11
ER -