Selective effector coupling of muscarinic acetylcholine receptor subtypes

K. Fukuda; T. Kubo; A. Maeda; I. Akiba; H. Bujo; J. Nakai; M. Mishina; H. Higashida; E. Neher; A. Marty; S. Numa

Selective effector coupling of muscarinic acetylcholine receptor subtypes

K. Fukuda, T. Kubo, A. Maeda, I. Akiba, H. Bujo, J. Nakai, M. Mishina, H. Higashida, E. Neher, A. Marty, S. Numa

DEN - Dental Sciences

Kyoto University

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Attempts have been made by means of recombinant DNA technology to understand the molecular basis of the functional heterogeneity of the muscarinic acetylcholine receptor (mAChR). Molecularly defined mAChR subtypes have been produced from the cloned DNAs in Xenopus oocytes and NG108-15 neuroblastoma-glioma hybrid cells as transient and stable expression systems, respectively, and agonist-induced cellular responses have been examined. The results obtained provide evidence that mAChR subtypes are selectively coupled with different effector systems, albeit not exclusively.

Original language	English
Pages (from-to)	4-10
Number of pages	7
Journal	Trends in Pharmacological Sciences
Volume	10
Issue number	SUPPL.
Publication status	Published - 1989

Cite this

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AU - Fukuda, K.

AU - Kubo, T.

AU - Maeda, A.

AU - Akiba, I.

AU - Bujo, H.

AU - Nakai, J.

AU - Mishina, M.

AU - Higashida, H.

AU - Neher, E.

AU - Marty, A.

AU - Numa, S.

PY - 1989

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AB - Attempts have been made by means of recombinant DNA technology to understand the molecular basis of the functional heterogeneity of the muscarinic acetylcholine receptor (mAChR). Molecularly defined mAChR subtypes have been produced from the cloned DNAs in Xenopus oocytes and NG108-15 neuroblastoma-glioma hybrid cells as transient and stable expression systems, respectively, and agonist-induced cellular responses have been examined. The results obtained provide evidence that mAChR subtypes are selectively coupled with different effector systems, albeit not exclusively.

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JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - SUPPL.

ER -

Selective effector coupling of muscarinic acetylcholine receptor subtypes

Abstract

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