Selective effector coupling of muscarinic acetylcholine receptor subtypes

K. Fukuda, T. Kubo, A. Maeda, I. Akiba, H. Bujo, J. Nakai, M. Mishina, H. Higashida, E. Neher, A. Marty, S. Numa

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Attempts have been made by means of recombinant DNA technology to understand the molecular basis of the functional heterogeneity of the muscarinic acetylcholine receptor (mAChR). Molecularly defined mAChR subtypes have been produced from the cloned DNAs in Xenopus oocytes and NG108-15 neuroblastoma-glioma hybrid cells as transient and stable expression systems, respectively, and agonist-induced cellular responses have been examined. The results obtained provide evidence that mAChR subtypes are selectively coupled with different effector systems, albeit not exclusively.

Original languageEnglish
Pages (from-to)4-10
Number of pages7
JournalTrends in Pharmacological Sciences
Issue numberSUPPL.
Publication statusPublished - 1989


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