Abstract
Effect of selenium on toxic side effects of cis-diamminedichloroplatinum (Cisplatin; CDDP) which is a potent anticancer drug containing platinum was examined. Remarkable protective effects of selenium against lethal and renal toxicity of CDDP were observed when selenite was administered to mice once a day after single injection of a lethal dose of CDDP. On the other hand antitumor activity of CDDP was hardly depressed by selenite.
| Original language | English |
|---|---|
| Pages (from-to) | 127-134 |
| Number of pages | 8 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 42 |
| Issue number | 1 |
| Publication status | Published - 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)