Selenium efficiently depressed toxic side effect of cis-diamminedichloroplatinum

A. Naganuma, M. Satoh, M. Yokoyama, N. Imura

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Effect of selenium on toxic side effects of cis-diamminedichloroplatinum (Cisplatin; CDDP) which is a potent anticancer drug containing platinum was examined. Remarkable protective effects of selenium against lethal and renal toxicity of CDDP were observed when selenite was administered to mice once a day after single injection of a lethal dose of CDDP. On the other hand antitumor activity of CDDP was hardly depressed by selenite.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'Selenium efficiently depressed toxic side effect of cis-diamminedichloroplatinum'. Together they form a unique fingerprint.

Cite this