TY - JOUR
T1 - Selenium Transport Mechanism via Selenoprotein P—Its Physiological Role and Related Diseases
AU - Saito, Yoshiro
N1 - Funding Information:
This study was supported in part by KAKENHI Grant Nos. 20H00488 and 20H05491 from the Japan Society for the Promotion of Science (JSPS) and Grant No. 20ek0210144h0001 and BINDS from Japan Agency for Medical Research and Development (AMED).
Publisher Copyright:
© Copyright © 2021 Saito.
PY - 2021/5/28
Y1 - 2021/5/28
N2 - Selenoprotein P (SELENOP) is selenium (Se)-containing protein in plasma, which is primarily produced in the liver. The “P” in SELENOP originated from the presence in plasma. SELENOP contains selenocysteine, a cysteine analog containing Se instead of sulfur. SELENOP is a multi-functional protein to reduce phospholipid hydroperoxides and to deliver Se from the liver to other tissues, such as those of the brain and testis, playing a pivotal role in Se metabolism and antioxidative defense. Decrease in SELENOP causes various dysfunctions related to Se deficiency and oxidative stress, while excessive SELENOP causes insulin resistance. This review focuses on the Se transport system of SELENOP, particularly its molecular mechanism and physiological role in Se metabolism. Furthermore, the chemical form of Se and its biological meaning is discussed.
AB - Selenoprotein P (SELENOP) is selenium (Se)-containing protein in plasma, which is primarily produced in the liver. The “P” in SELENOP originated from the presence in plasma. SELENOP contains selenocysteine, a cysteine analog containing Se instead of sulfur. SELENOP is a multi-functional protein to reduce phospholipid hydroperoxides and to deliver Se from the liver to other tissues, such as those of the brain and testis, playing a pivotal role in Se metabolism and antioxidative defense. Decrease in SELENOP causes various dysfunctions related to Se deficiency and oxidative stress, while excessive SELENOP causes insulin resistance. This review focuses on the Se transport system of SELENOP, particularly its molecular mechanism and physiological role in Se metabolism. Furthermore, the chemical form of Se and its biological meaning is discussed.
KW - ApoER2
KW - low-density lipoprotein receptor-related protein
KW - LRP1
KW - lysozome
KW - megalin
KW - selenium transport system
KW - selenoprotein synthesis
UR - http://www.scopus.com/inward/record.url?scp=85107574863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107574863&partnerID=8YFLogxK
U2 - 10.3389/fnut.2021.685517
DO - 10.3389/fnut.2021.685517
M3 - Review article
AN - SCOPUS:85107574863
SN - 2296-861X
VL - 8
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 685517
ER -
