Self-assembly of hybrid lipid membranes doped with hydrophobic organic molecules at the water/air interface

Xingyao Feng, Teng Ma, Daisuke Tadaki, Ayumi Hirano-Iwata

Research output: Contribution to journalArticlepeer-review


Because of their unique properties, including an ultrathin thickness (3-4 nm), ultrahigh resistivity, fluidity and self-assembly ability, lipid bilayers can be readily functionalized and have been used in various applications such as bio-sensors and bio-devices. In this study, we introduced a planar organic molecule: copper (II) 2,9,16,23-tetra-tert-butyl-29H,31H-phthalocyanine (CuPc) to dope lipid membranes. The CuPc/lipid hybrid membrane forms at the water/air interface by self-assembly. In this membrane, the hydrophobic CuPc molecules are located between the hydrophobic tails of lipid molecules, forming a lipid/CuPc/lipid sandwich structure. Interestingly, an air-stable hybrid lipid bilayer can be readily formed by transferring the hybrid membrane onto a Si substrate. We report a straightforward method for incorporating nanomaterials into a lipid bilayer system, which represents a new methodology for the fabrication of biosensors and biodevices.

Original languageEnglish
Article numbere60957
JournalJournal of Visualized Experiments
Issue number159
Publication statusPublished - 2020 May


  • Chemistry
  • Hybrid lipid membrane
  • Issue 159
  • Lipid bilayers
  • Organic molecule
  • Self-assembly
  • Thin film
  • Water/air interface


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