TY - JOUR
T1 - Self-Moisturizing Smart Contact Lens Employing Electroosmosis
AU - Kusama, Shinya
AU - Sato, Kaito
AU - Yoshida, Shotaro
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
This work was partly supported by Grant-in-Aids for Scientific Research A (18H04158) and Challenging Exploratory Research (18K19896) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors also acknowledge Dr. Hiroaki Suzuki at Menicon Co. for providing hydrogel samples.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Contact lenses (CLs) can be a cause of “dry eye syndrome” that can lead to corneal wounds and inflammation as well as a feeling of discomfort. To prevent the dry eye, it is important to keep the lens moist and maintain tears between the CL and the ocular surface. Here, the use of electroosmotic flow (EOF) in a CL is reported as a novel mechanism for antidehydration. A CL made from a charged hydrogel has served as the fluid conduit for EOF generation. The charge density of the gel is optimized by varying the composition ratio of anionic monomer having carboxyl group, by taking into account the efficiency of EOF generation and the mechanical strength of the hydrogels. By in situ monitoring of conductance and by microscope observations, it is successfully demonstrated that the upward EOF within CL is effective to maintain a moist lens. Biocompatible batteries (Mg/O2 battery and fructose/O2 enzymatic battery) are mounted on the CL to demonstrate the feasibility of a smart CL with a built-in power source for EOF-based self-moisturization.
AB - Contact lenses (CLs) can be a cause of “dry eye syndrome” that can lead to corneal wounds and inflammation as well as a feeling of discomfort. To prevent the dry eye, it is important to keep the lens moist and maintain tears between the CL and the ocular surface. Here, the use of electroosmotic flow (EOF) in a CL is reported as a novel mechanism for antidehydration. A CL made from a charged hydrogel has served as the fluid conduit for EOF generation. The charge density of the gel is optimized by varying the composition ratio of anionic monomer having carboxyl group, by taking into account the efficiency of EOF generation and the mechanical strength of the hydrogels. By in situ monitoring of conductance and by microscope observations, it is successfully demonstrated that the upward EOF within CL is effective to maintain a moist lens. Biocompatible batteries (Mg/O2 battery and fructose/O2 enzymatic battery) are mounted on the CL to demonstrate the feasibility of a smart CL with a built-in power source for EOF-based self-moisturization.
KW - biobatteries
KW - contact lenses
KW - dry eyes
KW - electroosmosis
KW - EOF-based moisturizing
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U2 - 10.1002/admt.201900889
DO - 10.1002/admt.201900889
M3 - Article
AN - SCOPUS:85075764571
SN - 2365-709X
VL - 5
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
IS - 1
M1 - 1900889
ER -