Sensitization of cells to ionizing radiation by chlorin e6Na

Yoshio Hosoi; Mieko Kawamura; Tatsuo Ido; Yoshihiro Takai; Keiichiro Ishii; Kenji Nemoto; Tetuya Ono; Shuichi Kimura; Kiyohiko Sakamoto

doi:10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X

Sensitization of cells to ionizing radiation by chlorin e₆Na

Yoshio Hosoi, Mieko Kawamura, Tatsuo Ido, Yoshihiro Takai, Keiichiro Ishii, Kenji Nemoto, Tetuya Ono, Shuichi Kimura, Kiyohiko Sakamoto

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated whether a hydrophilic photosensitizer, chlorin e₆Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation: Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.

Original language	English
Pages (from-to)	151-156
Number of pages	6
Journal	Radiation Oncology Investigations
Volume	6
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X
Publication status	Published - 1998

Keywords

Chlorin eNa
Hematoporphyrin
Sensitizer
X-irradiation

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiation
Oncology
Radiology Nuclear Medicine and imaging

Access to Document

10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X

Cite this

@article{1df53f65cae24ce5a00ad14f6a2c2973,

title = "Sensitization of cells to ionizing radiation by chlorin e6Na",

abstract = "We have investigated whether a hydrophilic photosensitizer, chlorin e6Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation: Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.",

keywords = "Chlorin eNa, Hematoporphyrin, Sensitizer, X-irradiation",

author = "Yoshio Hosoi and Mieko Kawamura and Tatsuo Ido and Yoshihiro Takai and Keiichiro Ishii and Kenji Nemoto and Tetuya Ono and Shuichi Kimura and Kiyohiko Sakamoto",

year = "1998",

doi = "10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X",

language = "English",

volume = "6",

pages = "151--156",

journal = "Radiation Oncology Investigations",

issn = "1065-7541",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Sensitization of cells to ionizing radiation by chlorin e6Na

AU - Hosoi, Yoshio

AU - Kawamura, Mieko

AU - Ido, Tatsuo

AU - Takai, Yoshihiro

AU - Ishii, Keiichiro

AU - Nemoto, Kenji

AU - Ono, Tetuya

AU - Kimura, Shuichi

AU - Sakamoto, Kiyohiko

PY - 1998

Y1 - 1998

N2 - We have investigated whether a hydrophilic photosensitizer, chlorin e6Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation: Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.

AB - We have investigated whether a hydrophilic photosensitizer, chlorin e6Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation: Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.

KW - Chlorin eNa

KW - Hematoporphyrin

KW - Sensitizer

KW - X-irradiation

UR - http://www.scopus.com/inward/record.url?scp=0031928631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031928631&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X

DO - 10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X

M3 - Article

C2 - 9727873

AN - SCOPUS:0031928631

SN - 1065-7541

VL - 6

SP - 151

EP - 156

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 4

ER -