Septic shock caused by a carbon dioxide-dependent and extended spectrum β-lactamase-producing Proteus mirabilis small colony variant in a long-term bedridden patient

Mizuka Kikuchi, Yasuko Suzuki, Shinji Okada, Asami Sato, Kengo Oshima, Takehisa Matsumoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Here, we report a 60-year-old chronically bedridden man with cerebral palsy who had septic shock following a history of urinary tract infection with extended spectrum β-lactamase-producing and auxotrophic Proteus mirabilis detected on blood and urine cultures. This auxotroph formed small colonies only on the blood agar at 24 h in 5% CO2, but not in the conditions without CO2, and lacked motility and some biochemical activities. The five-year history of stones in the right renal pelvis suggests chronic urinary tract infection with P. mirabilis requiring a 28-day antibiotic treatment. This paper highlights that the CO2-dependent P. mirabilis small colony variant may cause sepsis, probably due to chronic infection in uroliths, which should warrant immediate identification.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume28
Issue number3
DOIs
Publication statusPublished - 2022 Mar

Keywords

  • Auxotroph
  • Carbon dioxide-dependent
  • Proteus mirabilis
  • Small colony variant

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