Septoclasts expressing epidermal fatty acid-binding protein (E-FABP, FABP5) in endochondral ossification

Yasuhiko Bando, Hide Sakashita, Arata Nagasaka, Koji Sakiyama, Nobuko Tokuda, Shoichi Iseki, Yuji Owada, Osamu Amano

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Background: Long-chain fatty acids (LCFAs) and retinoic acid (RA) are abundant in the growth plates (GPs) of long bones; however, their roles have not been elucidated. We observed that epidermal fatty acid-binding protein (E-FABP/FABP5) with a high affinity for both LCFAs and RA is exclusively expressed in the septoclasts located at the chondro-osseous junction (COJ) of the GP. Highlights: E-FABP expressed in septoclasts is involved in both LCFA metabolism and RA signaling as an intracellular transporter of both LCFAs and RA. Septoclasts with shortened cytoplasmic processes are associated with cartilage resorptive activity downregulation because of E-FABP deficiency or excess or deficiency of RA. In ontogeny, the septoclasts are differentiated from the pericytes and involved in the resorption of the uncalcified matrix of the cartilage templates in endochondral ossification. Conclusion: Septoclasts originate from pericytes and express E-FABP to play crucial roles in uncalcified matrix resorption by LCFA metabolism and RA signaling during endochondral ossification.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalJournal of Oral Biosciences
Issue number1
Publication statusPublished - 2022 Mar


  • Endochondral ossification
  • Fatty acid-binding proteins
  • Mice
  • Pericytes
  • Retinoic acid


Dive into the research topics of 'Septoclasts expressing epidermal fatty acid-binding protein (E-FABP, FABP5) in endochondral ossification'. Together they form a unique fingerprint.

Cite this